Evidence map›Paper›PMID 33863785›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Unraveling the Mechanisms Underlying Irregularities in Inspiratory Rhythm Generation in a Mouse Model of Parkinson's Disease.

Luiz M Oliveira, Nathan A Baertsch, Thiago S Moreira, Jan-Marino Ramirez, Ana C Takakura

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Article
  5. Review
  6. Functional modulation of retrotrapezoid neurons drives fentanyl-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Inspiratory rhythm generation is stabilized byJournal of neurophysiology · 2022
    Article
  14. Review
  15. Central Apneas Due to the CLIFAHDD Syndrome Successfully Treated with Pyridostigmine.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Luiz M OliveiraDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo 05508, Brazil.ORCID https://orcid.org/0000-0002-4071-4572
Nathan A BaertschCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98101.
Thiago S MoreiraDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo 05508, Brazil.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98101.
Ana C TakakuraDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo 05508, Brazil takakura@icb.usp.br.
Universidade de São Paulo · BRUniversity of Washington · US

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Homeostatic Plasticity of the Respiratory Rhythm Generating NetworkR00HL145004 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2021 to 2023
$747k
Homeostatic Plasticity of the Respiratory Rhythm Generating NetworkK99HL145004 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2019 to 2020
$209k
The role of Dbx1-derived medullary neurons for rhythm generation in the intact respiratory networkF32HL134207 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2016 to 2018
$139k
NHLBI NIH HHS F32 HL134207NHLBI NIH HHS K99 HL145004NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R00 HL145004NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder anatomically characterized by a progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). Much less known, yet clinically very important, are the detrimental effects on breathing associated with this disease. Consistent with the human pathophysiology, the 6-hydroxydopamine hydrochloride (6-OHDA) rodent model of PD shows reduced respiratory frequency (f

Indexed as

AnimalsFemaleInhalationMaleMiceMice, Inbred C57BLNeuronsParkinsonian DisordersRespiration DisordersRespiratory CenterbreathingmedullaParkinson's diseasephoto-activationpre-Bötzinger complexretrotrapezoid nucleus

Identifiers

PMID33863785
PMCPMC8260248
OpenAlexW3154198849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.