Observational studyArchives of disease in childhood. Fetal and neonatal edition2021
Neonatal hyperglycaemia is associated with worse neurodevelopmental outcomes in extremely preterm infants.
Observational study in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.Pediatric research · 2024Trial
- Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Clinical evaluation of a novel preterm standardised parenteral nutrition system for targeted macronutrient delivery.Pediatric research · 2026Article
- Identifying a Safety Threshold for Parenteral Glucose Intake in the Early Acute Phase of Preterm Neonates.Nutrients · 2026Article
- Early Neonatal Hyperglycemia, Risk Factors, and Adverse Outcomes in Extremely Preterm Infants: A Propensity-Matched Cohort Study.Children (Basel, Switzerland) · 2026Article
- Sodium Values During the First 10 Postnatal Days in Extremely-Low-Birth-Weight Infants and Long-Term Neurocognitive Outcomes: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- The neonatal continuous glucose monitoring paradox: why at-risk infants still lack access to a transformative technology-A call for needs-led innovation.Frontiers in medicine · 2026Article
- Association of hyperglycemia in extremely preterm infants with neurodevelopmental outcomes at 18 months of corrected age.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Glucose disturbances in very low birth weight infants nearing term age-results from the prospective LIGHT-study using continuous glucose monitoring.European journal of pediatrics · 2025Observational
- Management of Neonatal Hyperglycaemia in Sweden-A Survey Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Treatment of Severe Hyperglycemia in Extremely Preterm Infants Using Continuous Subcutaneous Insulin TherapyJournal of clinical research in pediatric endocrinology · 2024Article
- Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes.Pediatric research · 2024Review
- Insulin resistance prior to term age in very low birthweight infants: a prospective study.BMJ paediatrics open · 2024Observational
- Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: aMetabolic brain disease · 2023Article
- Neurodevelopmental consequences of early plasma sodium changes in very preterm infants.Pediatric research · 2022Article
- Neonatal Hyperglycemia and Neurodevelopmental Outcomes in Preterm Infants: A Review.Children (Basel, Switzerland) · 2022Review
- Early versus later initiation of parenteral nutrition for very preterm infants: a propensity score-matched observational study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Association between Neonatal Intakes and Hyperglycemia, and Left Heart and Aortic Dimensions at 6.5 Years of Age in Children Born Extremely Preterm.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the associations between neonatal hyperglycaemia and insulin treatment, versus long-term neurodevelopmental outcomes in children born extremely preterm. DESIGN AND
settingObservational national cohort study (Extremely Preterm Infants in Sweden Study) using prospectively and retrospectively collected data. Neurodevelopmental assessment was performed at 6.5 years of age. PATIENTS: 533 infants born <27 gestational weeks during 2004-2007; 436 survivors were assessed at 6.5 years. OUTCOME MEASURES: Neurodevelopmental disability (NDD), survival without moderate to severe NDD, Wechsler Intelligence Scale for Children IV Full scale intelligence quotient (WISC-IV FSIQ) and Movement Assessment Battery for Children 2 (MABC-2) total score.
resultsDuration of neonatal hyperglycaemia >8 mmol/L was associated with WISC-IV scores-for each day with hyperglycaemia there was a decrease of 0.33 points (95% CI 0.03 to 0.62) in FSIQ. Neonatal hyperglycaemia >8 mmol/L occurring on 3 consecutive days was associated with lower MABC-2 scores (adjusted mean difference: -4.90; 95% CI -8.90 to -0.89). For each day with hyperglycaemia >8 mmol/L, there was a decrease of 0.55 points (95% CI 0.17 to 0.93) in MABC-2 total score. Insulin treatment was not associated with any of the outcome measures.
conclusionNeonatal hyperglycaemia >8 mmol/L was associated with lower intelligence scores and worse motor outcomes at 6.5 years of age. Insulin treatment was not associated with either worsened or improved neurodevelopmental outcomes. Randomised controlled trials are needed to clarify the role of insulin in treating hyperglycaemia in extremely preterm infants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.