Evidence map›Paper›PMID 33863379›Full record

ArticleVeterinary research2021

Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein.

Jan P M Langeveld, Anne Balkema-Buschmann, Dieter Becher, Achim Thomzig, Romolo Nonno, Olivier Andréoletti, Aart Davidse, Michele A Di Bari, Laura Pirisinu, Umberto Agrimi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 5 countries.

Jan P M LangeveldDepartment of Infection Biology, Wageningen Bioveterinary Research (WBVR), 8221RA 39, Lelystad, The Netherlands. jan.langeveld@wur.nl.ORCID http://orcid.org/0000-0002-4165-3230
Anne Balkema-BuschmannInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493, Greifswald-Insel Riems, Germany.
Dieter BecherMICROMUN, Institut Für Mikrobiologische Forschung GmbH, 17489, Greifswald, Germany.
Achim ThomzigPrion and Prionoid Research Unit, Robert Koch-Institute, 13353, Berlin, Germany.
Romolo NonnoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore Di Sanità, 00161, Rome, Italy.
Olivier AndréolettiUMR INRAE/ENVT 1225 IHAP, École Nationale Vétérinaire de Toulouse, 31300, Toulouse, France.
Aart DavidseDepartment of Infection Biology, Wageningen Bioveterinary Research (WBVR), 8221RA 39, Lelystad, The Netherlands.
Michele A Di BariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore Di Sanità, 00161, Rome, Italy.
Laura PirisinuDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore Di Sanità, 00161, Rome, Italy.
Umberto AgrimiDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore Di Sanità, 00161, Rome, Italy.
Martin H Groschup
Michael BeekesPrion and Prionoid Research Unit, Robert Koch-Institute, 13353, Berlin, Germany.
Jason ShihDepartment of Poultry Science, North Carolina State University, Raleigh, NC, 27695-7608, USA.
Istituto Superiore di Sanità · ITRobert Koch Institute · DEWageningen University & Research · NLÉcole Nationale Vétérinaire de Toulouse · FRFriedrich-Loeffler-Institut · DEMicromun · DENorth Carolina State University · US

Funding

National Cattlemen's and Beef Association (USA) granted for period 2004-2006 years 2004-2006
6 · The paper itself

Abstract

The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrP

Indexed as

Hot TemperatureProteolysisAnimalsBacillus licheniformisCattleEncephalopathy, Bovine SpongiformMice, TransgenicPeptide HydrolasesPrion ProteinskeratinasePeptide HydrolasesPrion ProteinsBioassayBSEHeatInactivationInfectivityMolecular mechanismPrionPrPStrainZoonotic

Identifiers

PMID33863379
PMCPMC8052740
OpenAlexW3152558578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.