Evidence map›Paper›PMID 33863347›Full record

Observational studyItalian journal of pediatrics2021

Assessing patients' characteristics and treatment patterns among children with atopic dermatitis.

Davide Geat, Mattia Giovannini, Gabriele Barlocco, Riccardo Pertile, Manuela Pace, Francesca Mori, Elio Novembre, Giampiero Girolomoni, Mario Cristofolini, Ermanno Baldo

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Davide Geat *Department of Medicine, Section of Dermatology and Venerology, University of Verona, Verona, Italy.
Mattia Giovannini *Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
Gabriele Barlocco"Giovan Battista Mattei" Research Institute, Stenico, Italy.
Riccardo PertileDepartment of Clinical and Evaluative Epidemiology, Trento Health Service, Trento, Italy.
Manuela PaceDepartment of Pediatrics, S. Maria del Carmine Hospital, Rovereto, Italy.
Francesca MoriAllergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
Elio NovembreAllergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
Giampiero GirolomoniDepartment of Medicine, Section of Dermatology and Venerology, University of Verona, Verona, Italy.
Mario Cristofolini"Giovan Battista Mattei" Research Institute, Stenico, Italy.
Ermanno Baldo"Giovan Battista Mattei" Research Institute, Stenico, Italy. ermanno@baldo.tn.it.
Azienda Ospedaliero Universitaria San Giovanni Battista · ITMeyer Children's Hospital · ITUniversity of Verona · ITOspedale Santa Maria · ITProvincia Autonoma di Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtopic dermatitis (AD) is the most common immune-mediated skin disease in childhood. Several treatment options for pediatric AD, both topical and systemic, are currently available. We carried out a single-center observational study with the aim of describing characteristics and treatment patterns in pediatric AD patients.

methodsThe study included 867 patients aged ≤16 years (females 50.5%, mean patient's age 5.9 years, standard deviation ±3.6 years) with a previous doctor-confirmed diagnosis of AD who underwent balneotherapy at the Comano Thermal Spring Water Center (Comano, Trentino, Italy) from April to October 2014.

resultsAmong the patients included in the study, 41.2% had mild (SCORing Atopic Dermatitis, SCORAD 0-15), 43.6% moderate (SCORAD 16-40) and 15.2% severe AD (SCORAD > 40). A higher occurrence of reported food allergy was observed among children with more severe AD (p < 0.0001), while no association was found between AD severity and reported inhalant allergy or passive smoking (p = 0.15 and 0.92, respectively). Emollients (55.1%) and topical corticosteroids (TCS; 45.7%) were the main treatment options used in the previous month. The use of oral steroids and topical calcineurin inhibitors (TCI) was considerably less common (6.3 and 4.5%, respectively), while no patients were on systemic agents other than steroids. Among patients with severe AD, 9.8% had not used TCS, TCI or any systemic treatments. Moreover, 20.0% of the patients in the study population had followed elimination diets, although only 27.2% of them had a reported food allergy.

conclusionsA significant difference in the prevalence of reported food allergy emerged across the different AD severity categories. Furthermore, although further data are necessary to confirm our findings, undertreatment in children with AD appeared to be very common, at least among those attending the Comano Thermal Spring Water Center. Moreover, many patients followed elimination diets in the absence of reported food allergy.

Indexed as

Administration, CutaneousAdministration, OralAdolescentBalneologyCalcineurin InhibitorsChildChild, PreschoolDermatitis, AtopicEmollientsFemaleFood HypersensitivityGlucocorticoidsHumansItalyMaleSeverity of Illness IndexCalcineurin InhibitorsEmollientsGlucocorticoidsAtopic dermatitisChildrenComano thermal spring waterEmollientsFood allergy

Identifiers

PMID33863347
PMCPMC8052729
OpenAlexW3155577502

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.