Evidence map›Paper›PMID 33863318›Full record

ArticleRespiratory research2021

Analysis of single nucleotide polymorphisms in chronic beryllium disease.

Björn C Frye, Karoline I Gaede, Cesare Saltini, Milton D Rossman, Dimitri S Monos, Ken D Rosenman, Christine R Schuler, Ainsley Weston, Ralf Wegner, Rainer Noth and 4 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Björn C FryeDepartment of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3520-1868
Karoline I GaedeBioMaterial Bank Nord, Research Center Borstel, Leibniz Lung Center, 23845 Borstel, Parkallee 35, Germany.
Cesare SaltiniDepartment of Medicine, University of Florida, 1600 Archer Rd, Gainesville, 32610, FL, USA.
Milton D RossmanPulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, USA.
Dimitri S MonosPulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, USA.
Ken D RosenmanDivision of Occupational and Environmental Medicine, Department of Medicine, Michigan State University, East Lansing, MI, USA.
Christine R SchulerCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Ainsley WestonCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Ralf WegnerInstitute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rainer NothInstitute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany.
Gernot ZisselDepartment of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Stefan SchreiberInstitute for Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany.
Michael NothnagelDepartment of Statistical Genetics and Bioinformatics, Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Joachim Müller-QuernheimDepartment of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany. joachim.mueller-quernheim@uniklinik-freiburg.de.
University of Freiburg · DECenters for Disease Control and Prevention · USChristian-Albrechts-Universität zu Kiel · DEUniversity of Pennsylvania · USMichigan State University · USResearch Center Borstel - Leibniz Lung Center · DEUniversität Hamburg · DEUniversity of Cologne · DEUniversity of Florida Health · US

Funding

Deutscher Forschungsgemeinschaft / German Research Foundation Mu692/7-1
6 · The paper itself

Abstract

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.

Indexed as

Polymorphism, Single NucleotideBerylliosisBerylliumButyrophilinsChronic DiseaseDNAFemaleHumansMaleOccupational ExposureBerylliumBTNL2 protein, humanButyrophilinsDNAAnnexin A11Berylliosis chronicBeryllium diesaseBTNL2GeneticSarcoidosis

Identifiers

PMID33863318
PMCPMC8051053
OpenAlexW3156590642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.