ArticleBMC genomics2021
Long non-coding RNA pairs to assist in diagnosing sepsis.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- LINC02363: a potential biomarker for early diagnosis and treatment of sepsis.BMC immunology · 2025Pooled it
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- RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects.Molecular oncology · 2026Article
- STAHD: a scalable and accurate method to detect spatial domains in high-resolution spatial transcriptomics data.Bioinformatics (Oxford, England) · 2026Article
- Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade.iScience · 2025Article
- Applications of gene pair methods in clinical research: advancing precision medicine.Molecular biomedicine · 2025Review
- Less is more: relative rank is more informative than absolute abundance for compositional NGS data.Briefings in functional genomics · 2025Review
- Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review.Frontiers in pharmacology · 2025Review
- Biliary HMGB1 levels and biochemical indices in the assessment of acute obstructive septic cholangitis combined with septic shock.Clinics (Sao Paulo, Brazil) · 2025Article
- scMMAE: masked cross-attention network for single-cell multimodal omics fusion to enhance unimodal omics.Briefings in bioinformatics · 2024Article
- PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis.Briefings in bioinformatics · 2024Article
- Diagnostic and Predictive Value of LncRNA MCM3AP-AS1 in Sepsis and Its Regulatory Role in Sepsis-Induced Myocardial Dysfunction.Cardiovascular toxicology · 2024Article
- scCaT: An explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing.PLoS computational biology · 2024Article
- Pairwise analysis of gene expression for oral squamous cell carcinoma via a large-scale transcriptome integration.Journal of cellular and molecular medicine · 2024Article
- Logistic regression and other statistical tools in diagnostic biomarker studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Review
- Deep learning model to discriminate diverse infection types based on pairwise analysis of host gene expression.iScience · 2024Article
- Diagnostic Prediction of portal vein thrombosis in chronic cirrhosis patients using data-driven precision medicine model.Briefings in bioinformatics · 2023Article
- MrGPS: an m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients.Briefings in bioinformatics · 2023Article
- Co-expression module analysis reveals high expression homogeneity for both coding and non-coding genes in sepsis.BMC genomics · 2023Article
- The Role of Transcriptomics in Redefining Critical Illness.Critical care (London, England) · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is the major cause of death in Intensive Care Unit (ICU) globally. Molecular detection enables rapid diagnosis that allows early intervention to minimize the death rate. Recent studies showed that long non-coding RNAs (lncRNAs) regulate proinflammatory genes and are related to the dysfunction of organs in sepsis. Identifying lncRNA signature with absolute abundance is challenging because of the technical variation and the systematic experimental bias.
resultsCohorts (n = 768) containing whole blood lncRNA profiling of sepsis patients in the Gene Expression Omnibus (GEO) database were included. We proposed a novel diagnostic strategy that made use of the relative expressions of lncRNA pairs, which are reversed between sepsis patients and normal controls (eg. lncRNA
conclusionOur study identified 14 lncRNA pairs as signature that can facilitate the diagnosis of septic patients at an intervenable point when clinical manifestations are not dramatic. Also, the computational procedure can be generalized to a standard procedure for discovering diagnostic molecule signatures.
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