ArticleJournal of neurosurgery2021
Development of a common peroneal nerve injury model in domestic swine for the study of translational neuropathic pain treatments.
Article in Journal of neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Longitudinal multimodal assessment of neuropathy in a porcine neuritis model.Journal of neuroscience methods · 2026Article
- Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury.Molecular therapy. Methods & clinical development · 2025Article
- Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model.Frontiers in cell and developmental biology · 2025Article
- Spared ulnar nerve injury results in increased layer III-VI excitability in the pig somatosensory cortex.Lab animal · 2024Article
- Metagenome-assembled genomes from microbiomes fermenting dairy coproducts.Microbiology resource announcements · 2024Article
- Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury.Research square · 2023Article
- Non-invasive central nervous system assessment of a porcine model of neuropathic pain demonstrates increased latency of somatosensory-evoked potentials.Journal of neuroscience methods · 2023Article
- Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain.Journal of neurosurgery · 2021Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo date, muscular and bone pain have been studied in domestic swine models, but the only neuropathic pain model described in swine is a mixed neuritis model. Common peroneal nerve injury (CPNI) neuropathic pain models have been utilized in both mice and rats.
methodsThe authors developed a swine surgical CPNI model of neuropathic pain. Behavioral outcomes were validated with von Frey filament testing, thermal sensitivity assessments, and social and motor scoring. Demyelination of the nerve was confirmed through standard histological assessment. The contralateral nerve served as the control.
resultsCPNI induced mechanical and thermal allodynia (p < 0.001 [n = 10] and p < 0.05 [n = 4], respectively) and increased pain behavior, i.e., guarding of the painful leg (n = 12). Myelin protein zero (P0) staining revealed demyelination of the ligated nerve upstream of the ligation site.
conclusionsIn a neuropathic pain model in domestic swine, the authors demonstrated that CPNI induces demyelination of the common peroneal nerve, which the authors hypothesize is responsible for the resulting allodynic pain behavior. As the anatomical features of domestic swine resemble those of humans more closely than previously used rat and mouse models, utilizing this swine model, which is to the authors' knowledge the first of its kind, will aid in the translation of experimental treatments to clinical trials.
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