Evidence map›Paper›PMID 33862423›Full record

ReviewCurrent opinion in neurobiology2021

Molecular mechanisms of axo-axonic innervation.

Fabrice Ango, Nicholas Biron Gallo, Linda Van Aelst

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Fabrice AngoINM, University of Monpellier, INSERM, CNRS, Monpellier, France.
Nicholas Biron GalloCold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.
Linda Van AelstCold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA. Electronic address: vanaelst@cshl.edu.
Cold Spring Harbor Laboratory · USCentre National de la Recherche Scientifique · FR

Funding

Molecular and cellular mechanisms governing interneuron development and connectivityR01MH119819 · NIMH · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2019 to 2023
$3.3M
Neurodevelopmental Disorder-Associated Rho Regulators in Neocortical DevelopmentR01NS116897 · NINDS · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2020 to 2024
$2.9M
Molecular mechanisms governing axo-axonic subcellular target recognition in the neocortexF31MH117871 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI GALLO, NICHOLAS BIRON · 2018 to 2020
$70k
NIMH NIH HHS F31 MH117871NIMH NIH HHS R01 MH119819NINDS NIH HHS R01 NS116897
6 · The paper itself

Abstract

One of the most intriguing features of inhibitory synapses is the precision by which they innervate their target, not only at the cellular level but also at the subcellular level (i.e. axo-dendritic, axo-somatic, or axo-axonic innervation). In particular, in the cerebellum, cortex, and spinal cord, distinct and highly specialized GABAergic interneurons, such as basket cells, chandelier cells, and GABApre interneurons, form precise axo-axonic synapses, allowing them to directly regulate neuronal output and circuit function. In this article, we summarize our latest knowledge of the cellular and molecular mechanisms that regulate the establishment and maintenance of axo-axonic synapses in these regions of the CNS. We also detail the key roles of the L1CAM family of cell adhesion molecules in such GABAergic subcellular target recognition.

Indexed as

AxonsInterneuronsCerebral CortexSynapses

Identifiers

PMID33862423
PMCPMC8714040
OpenAlexW3156257192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.