Evidence map›Paper›PMID 33862069›Full record

ArticleThe Journal of investigative dermatology2021

Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin.

Anna Celli, Chia-Ling Tu, Elise Lee, Daniel D Bikle, Theodora M Mauro

Open access · greenAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
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  11. Article
  12. Store-operated calcium channels in skin.Frontiers in physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anna CelliDepartment of Dermatology, SFVAHCS Medical Center and University of California San Francisco, San Francisco, California, USA.
Chia-Ling TuEndocrine Unit, San Francisco VA Medical Center (SFVAMC), San Francisco, California, USA; Department of Medicine, University of California-San Francisco (UCSF), San Francisco, California, USA.
Elise LeeDepartment of Dermatology, SFVAHCS Medical Center and University of California San Francisco, San Francisco, California, USA.
Daniel D BikleDepartments of Medicine and Dermatology, UCSF Staff Physician, SF Department of Health Affairs Medical Center, San Francisco, California, USA.
Theodora M MauroDepartment of Dermatology, SFVAHCS Medical Center and University of California San Francisco, San Francisco, California, USA. Electronic address: thea.mauro@ucsf.edu.
University of California San Francisco Medical Center · USHealth Affairs · USSan Francisco VA Medical Center · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
Pathogenesis and Therapy of Ichthyosis in Disorders of Lipid MetabolismR01AR061106 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2022
$3.3M
ATP2A2-Regulated Keretinocyted Ca2+ Signaling MechanismsR01AR051930 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2006 to 2019
$3.2M
Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and functionI01BX003814 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2018 to 2021
–
BLRD VA I01 BX003814NCI NIH HHS P30 CA082103NIAMS NIH HHS R01 AR051930NIAMS NIH HHS R01 AR061106
6 · The paper itself

Abstract

The calcium-sensing receptor (CaSR) drives essential calcium ion (Ca

Indexed as

Aged, 80 and overAnimalsCadherinsCalcium SignalingCell AdhesionCells, CulturedHumansMiceReceptors, Calcium-SensingSkin AgingStromal Interaction Molecule 1CadherinsReceptors, Calcium-SensingStromal Interaction Molecule 1

Identifiers

PMID33862069
PMCPMC8526647
OpenAlexW3156837984

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.