Evidence map›Paper›PMID 33861957›Full record

ArticleCell2021

Lack of evidence for a role of PIWIL1 variants in human male infertility.

M S Oud, L Volozonoka, C Friedrich, S Kliesch, L Nagirnaja, C Gilissen, M K O'Bryan, R I McLachlan, K I Aston, F Tüttelmann and 2 more

Open access · bronzeAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. PIWI-interacting RNAs and human testicular function.WIREs mechanisms of disease · 2022
    Article
  6. Lower SpermatozoalInternational journal of molecular sciences · 2021
    Article
  7. Knockout Gene-Based Evidence for PIWI-Interacting RNA Pathway in Mammals.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 6 countries.

M S OudDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
L VolozonokaScientific Laboratory of Molecular Genetics, Riga Stradins University, LV-1007, Riga, Latvia.
C FriedrichInstitute of Reproductive Genetics, University of Münster, Münster, Germany.
S KlieschDepartment of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany.
L NagirnajaDivision of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
C GilissenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
M K O'BryanSchool of Biological Sciences, Monash University, Clayton, Melbourne, Australia; School of BioSciences, Faculty of Science, The University of Melbourne, Parkville, Melbourne, Australia.
R I McLachlanHudson Institute of Medical Research, Clayton, Melbourne, Australia; Department of Obstetrics and Gynecology, Monash University, Clayton, Melbourne, Australia.
K I AstonDivision of Urology, Department of Surgery, University of Utah, Salt Lake City, UT, USA.
F TüttelmannInstitute of Reproductive Genetics, University of Münster, Münster, Germany.
D F ConradDivision of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
J A VeltmanBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. Electronic address: joris.veltman@newcastle.ac.uk.
Oregon National Primate Research Center · USRadboud University Nijmegen · NLUniversity of Münster · DEHudson Institute of Medical Research · AUNewcastle University · GBRiga Stradiņš University · LVThe University of Melbourne · AUUniversity Hospital Münster · DEUniversity of Utah · US

Funding

GENOMICS OF SPERMATOGENIC IMPAIRMENTR01HD078641 · NICHD · WASHINGTON UNIVERSITY · PI Kenneth Ivan Aston, DONALD F. CONRAD · 2014 to 2026
$6.3M
NICHD NIH HHS R01 HD078641Wellcome Trust 209451Wellcome Trust 209451/Z/17/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AzoospermiaInfertility, MaleArgonaute ProteinsHumansMaleArgonaute ProteinsPIWIL1 protein, humanazoospermiaclinical validity assessmentD-boxexome sequencingHIWImale infertilityMIWIoligozoospermiapiRNAPIWIL1single molecule molecular inversion probes

Identifiers

PMID33861957
PMCPMC7614813
OpenAlexW3155956338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.