ArticleCell2021
Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment.
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
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Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disrupted reward processing in Parkinson's disease and its relationship with dopamine state and neuropsychiatric syndromes: a systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2022Pooled it
- Randomized trial on the impact of card Game-Based teaching on learning and memory retention of neurological syndromes.BMC medical education · 2025Trial
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Region-specific weighting of sensory intensity and reward prediction error by dopamine signals.iScience · 2026Article
- Differential contributions of striatal dopaminergic pathways to visuomotor conditional learning.Psychopharmacology · 2026Article
- Quantifying the spatiotemporal mechanical dynamics of engineered cardiac microbundles.PLoS computational biology · 2026Article
- Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys.bioRxiv : the preprint server for biology · 2026Article
- Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Planar, spiral, and concentric traveling waves distinguish behavioral states in human memory.Nature communications · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Acetylcholine demixes heterogeneous dopamine signals for learning and moving.Nature neuroscience · 2026Article
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum.eLife · 2026Article
- Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.bioRxiv : the preprint server for biology · 2025Article
- Timescales of dopamine release in the striatum as a window into hierarchical control.Current opinion in behavioral sciences · 2025Article
- Unveiling Dopamine and Met-Enkephalin Dynamics: Simultaneous Co-Detection in Rat Striatum.Analytical chemistry · 2025Article
- Parkinsonian striatal acetylcholine dynamics are refractory to L-DOPA treatment.bioRxiv : the preprint server for biology · 2025Article
- Trial-by-trial learning of successor representations in human behavior.bioRxiv : the preprint server for biology · 2025Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
54 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Significant evidence supports the view that dopamine shapes learning by encoding reward prediction errors. However, it is unknown whether striatal targets receive tailored dopamine dynamics based on regional functional specialization. Here, we report wave-like spatiotemporal activity patterns in dopamine axons and release across the dorsal striatum. These waves switch between activational motifs and organize dopamine transients into localized clusters within functionally related striatal subregions. Notably, wave trajectories were tailored to task demands, propagating from dorsomedial to dorsolateral striatum when rewards are contingent on animal behavior and in the opponent direction when rewards are independent of behavioral responses. We propose a computational architecture in which striatal dopamine waves are sculpted by inference about agency and provide a mechanism to direct credit assignment to specialized striatal subregions. Supporting model predictions, dorsomedial dopamine activity during reward-pursuit signaled the extent of instrumental control and interacted with reward waves to predict future behavioral adjustments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.