Evidence map›Paper›PMID 33861942›Full record

ArticleNeuron2021

Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats.

Weisheng Wang, Peter J Schuette, Jun Nagai, Brooke Christine Tobias, Fernando Midea Cuccovia V Reis, Shiyu Ji, Miguel A X de Lima, Mimi Q La-Vu, Sandra Maesta-Pereira, Meghmik Chakerian and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Paternal behavior is controlled by preoptic Trpc5 neurons.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Hypothalamic Control of Learned Flight Induced by Threat Imminence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Weisheng WangDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Peter J SchuetteDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jun NagaiDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brooke Christine TobiasDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Fernando Midea Cuccovia V ReisDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shiyu JiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Miguel A X de LimaDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Mimi Q La-VuDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sandra Maesta-PereiraDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Meghmik ChakerianDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Saskia J LeonardDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lilly LinDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Amie L SeverinoDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Catherine M CahillDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Newton S CanterasDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Baljit S KhakhDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jonathan C KaoDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Avishek AdhikariDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: avi@psych.ucla.edu.

Funding

Dissection of Hypothalamic-Brainstem Circuits in Panic-Related Escape BehaviorR01MH119089 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADHIKARI, AVISHEK · 2019 to 2023
$2.1M
Dissection of the anxiety suppression circuitryR00MH106649 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADHIKARI, AVISHEK · 2017 to 2019
$747k
Dissecting Neural Control of Panic-Related BehaviorsF31MH121050 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LA-VU, MY QUYNH · 2020 to 2022
$92k
NIMH NIH HHS F31 MH121050NIMH NIH HHS R00 MH106649NIMH NIH HHS R01 MH119089
6 · The paper itself

Abstract

Naturalistic escape requires versatile context-specific flight with rapid evaluation of local geometry to identify and use efficient escape routes. It is unknown how spatial navigation and escape circuits are recruited to produce context-specific flight. Using mice, we show that activity in cholecystokinin-expressing hypothalamic dorsal premammillary nucleus (PMd-cck) cells is sufficient and necessary for context-specific escape that adapts to each environment's layout. In contrast, numerous other nuclei implicated in flight only induced stereotyped panic-related escape. We reasoned the dorsal premammillary nucleus (PMd) can induce context-specific escape because it projects to escape and spatial navigation nuclei. Indeed, activity in PMd-cck projections to thalamic spatial navigation circuits is necessary for context-specific escape induced by moderate threats but not panic-related stereotyped escape caused by perceived asphyxiation. Conversely, the PMd projection to the escape-inducing dorsal periaqueductal gray projection is necessary for all tested escapes. Thus, PMd-cck cells control versatile flight, engaging spatial navigation and escape circuits.

Indexed as

Escape ReactionSpatial NavigationAnimalsFemaleHypothalamus, PosteriorMaleMiceMice, Inbred C57BLNeural PathwaysPeriaqueductal GrayRatsRats, Long-EvansThalamusanterior medial ventral thalamuscalcium imagingDorsal premammillary nucleusDorsolateral periaqueductal grayEscapeFearhypercapniaoptogeneticsPanicPredator

Identifiers

PMID33861942
PMCPMC8178241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.