ArticlePloS one2021
The bone bridge significantly affects the decrease in bone mineral density measured with quantitative computed tomography in ankylosing spondylitis.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Comprehensive analysis of spinal sagittal balance, spinal bone mineral density, and pulmonary function in severe ankylosing spondylitis using quantitative computed tomography.BMC musculoskeletal disorders · 2026Article
- Clinical Characteristics and a New Classification System of Mono-Segmental Thoracic and Lumbar Nonfusion in Patients With Ankylosing Spondylitis.Orthopaedic surgery · 2026Article
- Development and validation of a nomogram for predicting low bone mineral density in male patients with ankylosing spondylitis.Frontiers in medicine · 2025Article
- Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis.Journal of clinical medicine · 2024Article
- The state of bone mineral density in men with ankylosing spondylitis and its relationship with the course of the disease.Reumatologia · 2024Article
- Syndesmophyte Growth in Ankylosing Spondylitis: from Laboratory to Bedside.Current rheumatology reports · 2023Review
- Low-dose CT hounsfield units: a reliable methodology for assessing vertebral bone density in radiographic axial spondyloarthritis.RMD open · 2022Article
- The applicability of trabecular bone score for osteoporosis diagnosis in ankylosing spondylitis.Rheumatology international · 2022Article
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8 authors at 1 institution in 1 country.
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Abstract
INTRODUCTION AND
objectiveAnkylosing spondylitis (AS) has characteristics of spinal bone bridge and fusion. Although BMD reduction in AS may be presumed to be due to spinal inflammation, this study was designed to confirm whether immobilization of the spine due to syndesmophytes is related to BMD reduction, as immobilization itself is a risk factor for BMD reduction.
methodsAmong male patients diagnosed with AS according to the modified New York criteria, those who underwent bone density tests with quantitative computed tomography (QCT) were retrospectively analyzed through a chart review. The correlation between the presence or absence of bone bridges for each vertebral body level of the L spine confirmed with radiography and BMD confirmed with QCT was analyzed.
resultsA total of 47 male patients with AS were enrolled. The mean patient age was 46.8 ± 8.2 years, and the mean disease duration was 7.9 ± 6.4 years. The trabecular BMD of the lumbar spine (L1-L4) ranged from 23.1 to 158.45 mg/cm3 (mean 102.2 ± 37 mg/cm3), as measured with QCT. The lumbar BMD measurements showed that 30 patients (63.8%) had osteopenia or osteoporosis. Bone bridge formation showed a negative correlation with BMD. Low BMD was significantly correlated with bone bridge in the vertebral body (p < 0.05). Positive correlations were observed between bone bridge score and BASMI flexion score, whereas significant negative correlations were found between BMD and BASMI flexion score (p < 0.05).
conclusionDecreased mobility of the vertebrae due to bone bridge formation affects the decrease in BMD in patients with AS.
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