Evidence map›Paper›PMID 33861389›Full record

ArticleInternational journal of colorectal disease2021

Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study.

Je-Ming Hu, Jia-Jheng Wu, Chih-Hsiung Hsu, Yong-Chen Chen, Yu-Feng Tian, Pi-Kai Chang, Chao-Yang Chen, Yu-Ching Chou, Chien-An Sun

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In one paragraph

Article in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Je-Ming HuGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan.
Jia-Jheng WuSchool of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Chih-Hsiung HsuSchool of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Yong-Chen ChenDepartment of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Yu-Feng TianDivision of Colorectal Surgery, Department of Surgery, Chi-Mei Medical Center, Tainan City, Taiwan.
Pi-Kai ChangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan.
Chao-Yang ChenDivision of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Yu-Ching ChouSchool of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Chien-An SunBig Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. 040866@mail.fju.edu.tw.ORCID http://orcid.org/0000-0001-9041-0537
National Defense Medical Center · TWTri-Service General Hospital · TWFu Jen Catholic University · TWChi Mei Medical Center · TW

Funding

Chi Mei Medical Center 105-CM-FJU-09
6 · The paper itself

Abstract

purposeSeveral studies have investigated the association between gastroesophageal reflux disease (GERD) and colorectal cancer (CRC) risk, but the presented scientific results are highly debatable. This study examined the longitudinal association between GERD and CRC in an Asian population.

methodsA retrospective cohort study was performed using the National Health Insurance Research Database of Taiwan. The study cohort comprised 45,828 individuals with newly diagnosed GERD (the GERD cohort) and 229,140 age, sex, and date of enrollment-matched patients without GERD (the comparison cohort) from 2000 to 2006. The primary outcome was the incidence of CRC. To estimate the effect of GERD on the risk of CRC, the Cox proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsThere were 785 newly diagnosed CRC patients in the 45,828 patients with GERD. Relatively, there were 2375 incident CRC cases in 229,140 patients without GERD. The incidence rate of CRC for the GERD cohort (17.60 per 10,000 person-years) was significantly higher than the corresponding incidence rate for the comparison cohort (10.22 per 10,000 person-years). After adjustment for confounders, GERD was associated with a significantly increased risk of CRC (adjusted HR,1.76; 95% CI, 1.62-2.90). Of note, a significant association between GERD and CRC risk was evident in both genders.

conclusionsIn conclusion, this nationwide population-based cohort study supports the hypothesis that GERD was associated with a significantly increased risk of CRC. Our findings warrant still further investigation of the underlying mechanisms related to carcinogenic effect of GERD on colorectal carcinoma.

Indexed as

Colorectal NeoplasmsGastroesophageal RefluxCohort StudiesFemaleHumansIncidenceMaleRetrospective StudiesRisk FactorsTaiwanColorectal cancerGastroesophageal reflux diseaseNational Health Insurance Research DatabaseRetrospective cohort study

Identifiers

PMID33861389
OpenAlexW3155569306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.