Evidence map›Paper›PMID 33861378›Full record

ArticleAIDS and behavior2021

Derivation of an HIV Risk Score for African Women Who Engage in Sex Work.

Alexandra C Willcox, Barbra A Richardson, Juma Shafi, Emmanuel Kabare, John Kinuthia, Walter Jaoko, Kishorchandra Mandaliya, Julie Overbaugh, R Scott McClelland

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alexandra C WillcoxUniversity of Washington School of Medicine, Seattle, WA, USA.
Barbra A RichardsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Juma ShafiDepartment of Medicine, University of Washington, Seattle, WA, USA.
Emmanuel KabareDepartment of Medicine, University of Washington, Seattle, WA, USA.
John KinuthiaKenyatta National Hospital, University of Nairobi, Nairobi, Kenya.
Walter JaokoDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Kishorchandra MandaliyaDepartment of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA.
Julie OverbaughHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
R Scott McClellandDepartment of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA. mcclell@uw.edu.ORCID http://orcid.org/0000-0003-2574-4201
University of Nairobi · KEUniversity of Washington · USFred Hutch Cancer Center · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1R37AI038518 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 1999 to 2019
$12.9M
Innate immune determinants of HIV rebound and persistenceR01HD103571 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JULIE M. OVERBAUGH · 2020 to 2026
$6.7M
RCT of an Implementation Science Tool to Integrate HIV testing into Family Planning Services K24HD088229 · NICHD · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2016 to 2020
$863k
National Institute of Allergy and Infectious Diseases R37 AI38518/HD103571National Institute of Child Health and Human Development K24 HD88229NIAID NIH HHS P30 AI027757NIAID NIH HHS R37 AI038518NICHD NIH HHS K24 HD088229NICHD NIH HHS R01 HD103571NIH HHS P30 AI027757
6 · The paper itself

Abstract

No tool exists to stratify HIV risk in contemporary African female sex worker (FSW) populations. Data from a cohort of HIV-negative FSWs in Mombasa, Kenya from 2010 to 2017 were used to conduct a survival analysis assessing predictors of HIV infection. Stepwise regression was used to construct a multivariable model that formed the basis for the score. Seventeen HIV infections occurred over 1247 person-years of follow-up contributed by 670 women. Using depot medroxyprogesterone acetate (DMPA), having a curable sexually transmitted infection (STI), and being married contributed points to the score. HIV incidence was 0.85/100 person-years in a lower-risk group and 3.10/100 person-years in a higher-risk group. In a cohort with overall HIV incidence < 1.50/100 person-years, this risk score identified a subgroup of FSWs with HIV incidence > 3.00/100 person-years, which is the threshold used by the World Health Organization for initiating pre-exposure prophylaxis (PrEP). If validated in an external population, this tool could be useful for targeted PrEP promotion among higher-risk FSWs.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisSex WorkersFemaleHumansIncidenceKenyaRisk FactorsSex WorkAfricaFemale sex workersHIVKenyaRisk score

Identifiers

PMID33861378
PMCPMC8763393
OpenAlexW3156035399

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.