Evidence map›Paper›PMID 33861370›Full record

ArticleCurrent microbiology2021

Biotechnological Potential of Eugenol and Thymol Derivatives Against Staphylococcus aureus from Bovine Mastitis.

Daiana O S Nunes, Rafaelle Vinturelle, Francislene J Martins, Thiago F Dos Santos, Alessandra Leda Valverde, Carlos Magno R Ribeiro, Helena C Castro, Evelize Folly

Abstract read
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In one paragraph

Article in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Natural compounds in the fight againstFrontiers in pharmacology · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Daiana O S NunesPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Rafaelle VinturellePrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Francislene J MartinsPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Thiago F Dos SantosInstituto de Química, Departamento de Química Orgânica, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Alessandra Leda ValverdePrograma de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Carlos Magno R RibeiroInstituto de Química, Departamento de Química Orgânica, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.
Helena C CastroPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil.ORCID https://orcid.org/0000-0001-5283-1541
Evelize FollyPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/no, Centro, Niterói, RJ, 24020-141, Brazil. evelizefolly@yahoo.com.br.ORCID http://orcid.org/0000-0001-6313-2447
Universidade Federal Fluminense · BR

Funding

CNPq 0000000Faperj 00000000
6 · The paper itself

Abstract

Bovine mastitis is an infectious disease that affects the mammary gland of dairy cattle with considerable economic losses. Staphylococcus aureus is the main microorganism involved in this highly contagious process, and the treatment is only using antibiotics. Currently, the search for new treatment and/or compounds is still in need due to microbial resistance. In this work, we evaluated the potential of eugenol and thymol derivatives against S. aureus strains from bovine mastitis. On that purpose, nine derivatives were synthesized from eugenol and thymol (1-9), and tested against 15 strains of S. aureus from subclinical bovine mastitis. Initially, the strains were evaluated for the biofilm production profile, and those with strong adherence were selected to the antimicrobial sensitivity determination in the Minimum Inhibitory Concentration (MIC) assays. Herein the compounds toxicity was also evaluated by in silico analysis using Osiris DataWarrior® software. The results showed that 60% of the strains were considered strongly adherent and three strains (S. aureus 4271, 4745 and 4746) were selected for the MIC tests. Among the nine eugenol and thymol derivatives tested, four were active against the evaluated strains (MIC = 32 µg mL

Indexed as

Mastitis, BovineStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsCattleEugenolFemaleMicrobial Sensitivity TestsStaphylococcus aureusThymolAnti-Bacterial AgentsEugenolThymol

Identifiers

PMID33861370
OpenAlexW3152916528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.