ArticleInternational urogynecology journal2022
A soft elastomer alternative to polypropylene for pelvic organ prolapse repair: a preliminary study.
Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Proteomic insights into vaginal mesh complications and treatment targets.Acta biomaterialia · 2025Article
- Significance of Textile Properties for the Design of a New Pelvic Implant to Treat Pelvic Organ Prolapse.International urogynecology journal · 2025Review
- Exosome injection as a prevention strategy for early postoperative mesh complications in a porcine model of sacrocolpopexy.NPJ Regenerative medicine · 2025Article
- Profiling of the macrophage response to polypropylene mesh burden in vivo.Biomaterials · 2025Article
- Vaginal host response to polycarbonate urethane, an alternative material for the repair of pelvic organ prolapse.Acta biomaterialia · 2024Article
- The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse.International urogynecology journal · 2024Review
- Polypropylene Pelvic Mesh: What Went Wrong and What Will Be of the Future?Biomedicines · 2023Review
- Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo.Acta biomaterialia · 2022Article
- Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introduction and hypothesisWe compared the impact of a mesh manufactured from the soft elastomer polydimethylsiloxane (PDMS) to that of a widely used lightweight polypropylene (PP) mesh. To achieve a similar overall device stiffness between meshes, the PDMS mesh was made with more material and therefore was heavier and less porous. We hypothesized that the soft polymer PDMS mesh, despite having more material, would have a similar impact on the vagina as the PP mesh.
methodsPDMS and PP meshes were implanted onto the vaginas of 20 rabbits via colpopexy. Ten rabbits served as sham. At 12 weeks, mesh-vagina complexes were explanted and assessed for contractile function, histomorphology, total collagen, and glycosaminoglycan content. Outcome measures were compared using one-way ANOVA and Kruskal-Wallis testing with appropriate post-hoc testing.
resultsRelative to sham, vaginal contractility was reduced following the implantation of PP (p = 0.035) but not the softer PDMS (p = 0.495). PP had an overall greater negative impact on total collagen and glycosaminoglycan content, decreasing by 53% (p < 0.001) and 54% (p < 0.001) compared to reductions of 35% (p = 0.004 and p < 0.001) with PDMS. However, there were no significant differences in the contractility, collagen fiber thickness, total collagen, and glycosaminoglycan content between the two meshes.
conclusionsDespite having a substantially higher weight, PDMS had a similar impact on the vagina compared to a low-weight PP mesh, implicating soft polymers as potential alternatives to PP. The notion that heavyweight meshes are associated with a worse host response is not applicable when comparing across materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.