Evidence map›Paper›PMID 33860459›Full record

ArticleHuman cell2021

Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor.

Tao Du, Guanqun Ju, Jun Zhou, Liang Zhong, Lu Rong, Wenxia Chen, Xiaoli Zhang, Ruijin Zhou, Degang Ding, Tongyu Ji

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Engineering of Immune Microenvironment for Enhanced Tissue Remodeling.Tissue engineering and regenerative medicine · 2022
    Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tao Du *Department of Urology, Zhengzhou University People's Hospital, Zhengzhou, China.
Guanqun Ju *Department of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jun ZhouDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China.
Liang ZhongDepartment of Urology, Shanghai Children Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu RongDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China.
Wenxia ChenDepartment of Pediatrics, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Xiaoli ZhangDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China.
Ruijin ZhouDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China.
Degang DingDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China. dingdgang@163.com.
Tongyu JiDepartment of Urology, Zhengzhou University People's Hospital, Zhengzhou, China. jity_wh@aliyun.com.
Zhengzhou University · CNHenan Provincial People's Hospital · CNFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CNSecond Military Medical University · CNShanghai Jiao Tong University · CN

Funding

23456 Talent Project of Henan Provincial People's Hospital ZC23456005Henan Province Medical Science and Technology Research Plan
6 · The paper itself

Abstract

The intraoperative ischemia in partial nephrectomy (PN) often leads to postoperative renal function impairment and fibrosis, which can be regulated by macrophage polarization. We have previously demonstrated that microvesicles derived from human Wharton's Jelly mesenchymal stromal cells (hWJMSC-MVs) attenuated renal ischemia-induced renal fibrosis and contained a substantial quantity of hepatocyte growth factor (HGF). Herein, we investigated whether MSC-MVs regulate macrophage polarization and ameliorate renal fibrosis following ischemia-PN via transferring HGF. A rat model of ischemia-PN was established by 45 min of left renal ischemia followed by removal of 1/3 upper left kidney. MSC-MVs were injected through the tail vein immediately after ischemia. Renal injury biomarkers were measured and histologic analysis was performed to analyze renal injury. A co-culture model of THP-1 macrophages and MSC-MVs was utilized. The expression of M1 markers and M2 markers were determined to evaluate macrophage polarization. MSC-MV administration significantly ameliorated renal inflammation, lesions, and fibrosis in ischemia-PN rats, and promoted M2 macrophage polarization both in rat remnant renal tissues and LPS-treated THP-1 cells. These effects of MSC-MVs were compromised when HGF expression was downregulated in MSC-MVs. Collectively, MSC-MVs promote M2 macrophage polarization and attenuate renal fibrosis following ischemia-PN via transferring HGF.

Indexed as

Gene ExpressionAnimalsCell-Derived MicroparticlesCell PolarityDisease Models, AnimalFibrosisHepatocyte Growth FactorHumansIntraoperative ComplicationsIschemiaKidneyMacrophagesMaleMesodermNephrectomyPostoperative ComplicationsHepatocyte Growth FactorFibrosisHepatocyte growth factorMacrophageMicro-vesiclesPartial nephrectomy

Identifiers

PMID33860459
OpenAlexW3154764177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.