ArticleEuropean journal of pediatrics2021
Reference serum creatinine levels according to sex, age, and height in children with Down syndrome.
Article in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Kidney and urogenital abnormalities in Down syndrome: a meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Age- and sex-specific serum creatinine reference curves in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Serum Creatinine Levels in Children With Down Syndrome: A Single-Centre Retrospective Study in Ireland.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Rethinking Creatinine in Children With Down Syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Review
- Population pharmacokinetics of valproic acid in children with epilepsy: Implications for dose tailoring when switching from oral syrup to sustained-release tablets.CPT: pharmacometrics & systems pharmacology · 2024Article
- Creatinine levels in French children with Down syndrome up to ten years old.European journal of pediatrics · 2024Article
- Kidney and urological involvement in Down syndrome: frequent, underestimated, but associated with impaired quality of life and risk of kidney failure.Pediatric nephrology (Berlin, Germany) · 2024Review
- Osteosarcopenic obesity and its components-osteoporosis, sarcopenia, and obesity-are associated with blood cell count-derived inflammation indices in older Chinese people.BMC geriatrics · 2022Article
- What is the cause of kidney dysfunction in a newborn with trisomy 21? Answers.Pediatric nephrology (Berlin, Germany) · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standard serum creatinine (S-Cr) levels in healthy children fluctuate with age and sex. However, it is unclear if this fluctuation in S-Cr levels is present for children with Down syndrome (DS) who show atypical growth rate. Therefore, we aimed to establish specific reference S-Cr levels for DS and compare them with the prevailing standard levels. We retrospectively reviewed 984 children with DS aged 3 months to 18 years who visited our medical center. Patients with diseases affecting S-Cr levels were excluded. We calculated the reference S-Cr levels according to sex, age, and length/height using medical records. A total of 3765 examinations of 568 children with DS were registered for this study. Ages and S-Cr levels were examined for boys (y = 0.032x + 0.20; r = 0.868, P < 0.0001), and girls (y = 0.024x + 0.23; r = 0.835, P < 0.0001). S-Cr levels in children aged >9 years were significantly higher in boys than in girls. The 430 children with DS aged 2-8 years were examined 1867 times. Height and S-Cr levels showed a significantly strong positive correlation (r = 0.670, P < 0.001) with regression equation y = 0.37x. The quintic equations calculated with S-Cr levels and length/height for boys (336 children, 2043 tests, r = 0.887) and girls (232 children, 1722 tests, r = 0.805) werey = - 6.132x
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