Evidence map›Paper›PMID 33860327›Full record

ArticleJournal of neuropathology and experimental neurology2021

Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease.

Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  5. Primary age-related tauopathy.Acta neuropathologica · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jamie M WalkerFrom the Department of Pathology and Laboratory Medicine, Upstate Medical University, Syracuse, New York, USA.
Yelena FudymDepartment of Pathology, State University of New York, Upstate Medical University, Syracuse, New York, USA.
Kurt FarrellDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Megan A IidaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kevin F BieniekFrom the Department of Pathology and Laboratory Medicine, Upstate Medical University, Syracuse, New York, USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Charles L WhiteDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
John F CraryDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Timothy E RichardsonFrom the Department of Pathology and Laboratory Medicine, Upstate Medical University, Syracuse, New York, USA.
The University of Texas Health Science Center at San Antonio · USIcahn School of Medicine at Mount Sinai · USSUNY Upstate Medical University · USThe University of Texas Southwestern Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
The Contribution of Age-Related Taupahtoies to Alzheimer's Disease-SupplementR01AG062348 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CRARY, JOHN FONDA, DICKSON, DENNIS WILLIAM · 2018 to 2022
$4.5M
Regulation of tau expression in Alzheimer disease and agingR01AG054008 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRARY, JOHN FONDA · 2016 to 2020
$4.0M
Mechanisms of Age-Related TauopathyR01NS095252 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Fonda Crary · 2015 to 2026
$3.4M
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6M
Post-doctoral fellowship in the mechanisms of age-related tauopathyF32AG056098 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FARRELL, KURT WILLIAM · 2017 to 2020
$190k
NIA NIH HHS F32 AG056098NIA NIH HHS R01 AG054008NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG062348NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS095252
6 · The paper itself

Abstract

Primary age-related tauopathy (PART) is a neurodegenerative entity defined as neurofibrillary degeneration generally restricted to the medial temporal region (Braak stage I-IV) with complete or near absence of diffuse and neuritic plaques. Symptoms range in severity but are generally milder and later in onset than in Alzheimer disease (AD). Recently, an early predilection for neurofibrillary degeneration in the hippocampal CA2 subregion has been demonstrated in PART, whereas AD neuropathologic change (ADNC) typically displays relative sparing of CA2 until later stages. In this study, we utilized a semiquantitative scoring system to evaluate asymmetry of neurofibrillary degeneration between left and right hippocampi in 67 PART cases and 17 ADNC cases. 49% of PART cases demonstrated asymmetric findings in at least one hippocampal subregion, and 79% of the asymmetric cases displayed some degree of CA2 asymmetry. Additionally, 19% of cases revealed a difference in Braak score between the right and left hippocampi. There was a significant difference in CA2 neurofibrillary degeneration (p = 0.0006) and CA2/CA1 ratio (p < 0.0001) when comparing the contralateral sides, but neither right nor left was more consistently affected. These data show the importance of analyzing bilateral hippocampi in the diagnostic evaluation of PART and potentially of other neurodegenerative diseases.

Indexed as

Age FactorsAgedAged, 80 and overAlzheimer DiseaseFemaleHippocampusHumansMaleMiddle AgedNeurofibrillary TanglesPlaque, AmyloidTauopathiestau ProteinsTemporal Lobetau ProteinsAlzheimer diseaseBraakCA1CA2Neurofibrillary tanglesPrimary age-related tauopathyThal

Identifiers

PMID33860327
PMCPMC8054137
OpenAlexW3155839915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.