Evidence map›Paper›PMID 33860285›Full record

ArticleBioinformatics research and applications : ... international symposium, ISBRA ... proceedings. ISBRA (Conference)2020

Dilated-DenseNet For Macromolecule Classification In Cryo-electron Tomography.

Shan Gao, Renmin Han, Xiangrui Zeng, Xuefeng Cui, Zhiyong Liu, Min Xu, Fa Zhang

Abstract read
In one paragraph

Article in Bioinformatics research and applications : ... international symposium, ISBRA ... proceedings. ISBRA (Conference), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shan GaoHigh Performance Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Renmin HanResearch Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao 266237, PR China.
Xiangrui ZengComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Xuefeng CuiSchool of Computer Science and Technology, Shandong University, Qingdao 266237, PR China.
Zhiyong LiuHigh Performance Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Min XuComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Fa ZhangHigh Performance Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
NIGMS NIH HHS P41 GM103712
6 · The paper itself

Abstract

Cryo-electron tomography (cryo-ET) combined with subtomogram averaging (STA) is a unique technique in revealing macromolecule structures in their near-native state. However, due to the macromolecular structural heterogeneity, low signal-to-noise-ratio (SNR) and anisotropic resolution in the tomogram, macromolecule classification, a critical step of STA, remains a great challenge. In this paper, we propose a novel convolution neural network, named 3D-Dilated-DenseNet, to improve the performance of macromolecule classification in STA. The proposed 3D-Dilated-DenseNet is challenged by the synthetic dataset in the SHREC contest and the experimental dataset, and compared with the SHREC-CNN (the state-of-the-art CNN model in the SHREC contest) and the baseline 3D-DenseNet. The results showed that 3D-Dilated-DenseNet significantly outperformed 3D-DenseNet but 3D-DenseNet is well above SHREC-CNN. Moreover, in order to further demonstrate the validity of dilated convolution in the classification task, we visualized the feature map of 3D-Dilated-DenseNet and 3D-DenseNet. Dilated convolution extracts a much more representative feature map.

Indexed as

Convolutional Neural NetworkCryo-electron TomographyObject ClassificationSubtomogram Averaging

Identifiers

PMID33860285
PMCPMC8046028

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.