ArticleBlood cancer discovery2021
TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia.
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Article in Blood cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
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- Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation.Cell communication and signaling : CCS · 2026Article
- Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells.PloS one · 2026Article
- cAMP promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics.bioRxiv : the preprint server for biology · 2025Article
- PAK4 phosphorylates and stabilizes MYC to promote acute myeloid leukemia.Cell insight · 2025Article
- Identification and validation of immune-associated gene signatures for prognostic prediction in acute myeloid leukemia.Medicine · 2025Article
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- Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias.Cell death discovery · 2025Review
- A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting.Discover oncology · 2025Article
- Lysosome targeted therapies in hematological malignancies.Frontiers in oncology · 2025Review
- Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC-Alarmin Axis.Blood cancer discovery · 2024Article
- Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.Nature reviews. Molecular cell biology · 2024Review
- Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells.Clinical & translational immunology · 2024Article
- CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma.Cancer research · 2023Article
- Balancing lysosome abundance in health and disease.Nature cell biology · 2023Review
- The Polyamine-Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma.Blood cancer discovery · 2023Article
- Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα.Acta pharmacologica Sinica · 2023Article
- Article
- p38 MAPK-dependent phosphorylation of TFEB promotes monocyte-to-macrophage differentiation.EMBO reports · 2023Article
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Authors and funding
22 authors at 6 institutions in 4 countries.
Seongseok YunDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-7343-1635
Nicole D VinceletteDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Xiaoqing YuDepartment of Bioinformatics and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Gregory W WatsonDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Mario R FernandezDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Chunying YangDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Taro HitosugiDepartment of Molecular Pharmacology and Experimental Therapeutics, and Department of Oncology, Mayo Clinic, Rochester, Minnesota.
Chia-Ho ChengDepartment of Bioinformatics and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Audrey R FreischelDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Ling ZhangDepartment of Pathology and Laboratory Medicine, Tampa, Florida.
Weimin LiDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Hsinan HouDepartment of Internal Medicine, National Taiwan University, Taipei, Taiwan.
Franz X SchaubDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Alexis R VedderDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Ling CenDepartment of Bioinformatics and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Kathy L McGrawDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Jungwon MoonDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Daniel J MurphyUniversity of Glasgow, Institute of Cancer Sciences, Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, United Kingdom.
Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Scott H KaufmannDepartment of Molecular Pharmacology and Experimental Therapeutics, and Department of Oncology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-4900-7145
Anders E BerglundDepartment of Bioinformatics and Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-0393-3530
John L ClevelandDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. john.cleveland@moffitt.org.
Moffitt Cancer Center · USMayo Clinic · USAdventHealth Tampa · USCancer Research UK Scotland Institute · GBNational Taiwan University · TWNeurological Research Institute · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MRole of CPT1A as a lysine succinyltransferase in tumorigenesisR01CA225680 · NCI · MAYO CLINIC ROCHESTER · PI HITOSUGI, TARO · 2018 to 2022
$1.8MTumor suppressor roles of TFEB in the development and maintenance of myeloid leukemiaK08CA237627 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI YUN, SEONGSEOK · 2019 to 2023
$1.1MRole of branched-chain amino catabolism in lymphopoiesis and lymphomagenesisF32CA203217 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI FERNANDEZ, MARIO R · 2016 to 2018
$184kCancer Research UK 27603NCI NIH HHS F32 CA203217NCI NIH HHS K08 CA237627NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA225680
Abstract
MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism and tumorigenesis. A variety of alterations drive
Indexed as
Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsIsocitrate DehydrogenaseLeukemia, Myeloid, AcuteProto-Oncogene Proteins c-mycSignal TransductionCell DifferentiationEpigenesis, GeneticHumansMutationBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsIsocitrate DehydrogenaseMYC protein, humanProto-Oncogene Proteins c-mycTFEB protein, human
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