Evidence map›Paper›PMID 33860183›Full record

ArticleACS pharmacology & translational science2021

Investigation of the Structure-Activity Relationships of Psilocybin Analogues.

Adam K Klein, Muhammad Chatha, Lauren J Laskowski, Emilie I Anderson, Simon D Brandt, Stephen J Chapman, John D McCorvy, Adam L Halberstadt

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 99 citations in OpenAlex.

  1. Crystal structures of new psychoactive substances 4-HO-DET and 4-AcO-DET.Acta crystallographica. Section E, Crystallographic communications · 2026
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  17. The Selective Serotonin 5‑HTACS pharmacology & translational science · 2025
    Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Adam K KleinDepartment of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, United States.
Muhammad ChathaDepartment of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, United States.
Lauren J LaskowskiDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, United States.
Emilie I AndersonDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, United States.
Simon D BrandtSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom.
Stephen J ChapmanIsomer Design, Toronto, Ontario M5B 2R3, Canada.
John D McCorvyDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, United States.
Adam L HalberstadtDepartment of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, United States.
Medical College of Wisconsin · USUniversity of California San Diego · USIsomer Design (Canada) · CALiverpool John Moores University · GB

Funding

Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
The Next Generation of Hallucinogens: A New Class of Synthetic Psychoactive DrugsR01DA041336 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALBERSTADT, ADAM L. · 2017 to 2020
$1.4M
NIDA NIH HHS R01 DA041336NIMH NIH HHS T32 MH018399
6 · The paper itself

Abstract

The 5-HT

Identifiers

PMID33860183
PMCPMC8033608
OpenAlexW3110733646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.