ArticleJGH open : an open access journal of gastroenterology and hepatology2021
Endoscopic and histological features of
Article in JGH open : an open access journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Incidence of Metachronous Gastric Cancer After Endoscopic Submucosal Dissection in Helicobacter pylori-uninfected Early Gastric Cancer.Digestive diseases and sciences · 2026Article
- Gastric dysplasia: an integrated classification of surface epithelium-derived precursor lesions.Virchows Archiv : an international journal of pathology · 2026Review
- Prevention of Gastric Cancer.Medicina (Kaunas, Lithuania) · 2026Review
- Integrated endoscopy: a new method for improving the diagnostic accuracy ofGastroenterology report · 2026Article
- <italic>Helicobacter pylori</italic>-Naïve Gastric Neoplasms: Clinicopathological and Molecular Features and Diagnostic Challenges.Digestion · 2026Review
- Gastric Epithelial Neoplasms in <italic>Helicobacter pylori</italic>-Uninfected Patients.Digestion · 2026Review
- Clinicopathological and endoscopic features of Helicobacter pylori infection-negative gastric cancer in Japan: a retrospective study.Clinical endoscopy · 2024Article
- Article
- Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -naïve patients: a multicenter retrospective analysis.Journal of gastroenterology · 2024Article
- Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- [Clinicopathological features ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Global research trends of endoscope in early gastric cancer: A bibliometric and visualized analysis study over past 20 years.Frontiers in oncology · 2023Article
- Clinicopathological and molecular characterization of early gastric adenocarcinoma in Helicobacter pylori-uninfected patients: emphasis on differentiated gastric adenocarcinoma.Journal of gastroenterology · 2022Article
- Changes in prevalence ofBMJ open · 2022Article
- Self-Renewal and Cancers of the Gastric Epithelium: An Update and the Role of the Lectin TFF1 as an Antral Tumor Suppressor.International journal of molecular sciences · 2022Review
- Gastric Signet-Ring Cell Carcinoma That Presented as an Elevated Lesion due to Fibromuscular Obliteration in the Lamina Propria.Case reports in gastrointestinal medicine · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimWith the increasing prevalence of persons without
methodsOf 1965 consecutive patients with early gastric cancer who underwent endoscopic resection between January 2009 and December 2017, we extracted 9 cases of HP-negative differentiated adenocarcinoma located in the antrum (HPN-DAA). The clinical data, endoscopic findings, and histopathological findings were reviewed.
resultsOf the nine patients with HPN-DAA, seven were male, and the median age was 53.8 years. The tumor arose from the pyloric gland mucosa in all cases. According to the endoscopic findings, the lesions were flat-elevated or depressed, mimicking varioliform gastritis. Magnifying endoscopy with narrow-band imaging showed the absence of a clear demarcation line or an irregular microvessel/surface pattern. As for the histopathological findings, eight of the nine lesions were diagnosed as high-grade dysplasia/intraepithelial neoplasia, while the remaining case was diagnosed as tubular adenocarcinoma with submucosal infiltration. The findings of immunohistochemistry confirmed that three cases were of the intestinal mucin phenotype and six were of the mixed gastric and intestinal mucin phenotype.
conclusionHPN-DAA is a very rarely occurring cancer that had never been recognized earlier. They belong to the new category of HP-negative cancers, and there seems to be a certain number of such cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.