Evidence map›Paper›PMID 33859805›Full record

ArticleACS medicinal chemistry letters2021

Synthesis of C6-Substituted Purine Nucleoside Analogues via Late-Stage Photoredox/Nickel Dual Catalytic Cross-Coupling.

James J Perkins, Valerie W Shurtleff, Alayna M Johnson, Abdellatif El Marrouni

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James J PerkinsMerck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
Valerie W ShurtleffMerck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
Alayna M JohnsonMerck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
Abdellatif El MarrouniMerck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleoside analogues have been and continue to be extremely important compounds in drug discovery. Despite the significant effort dedicated to their synthesis, medicinal chemistry campaigns around these structures are often hampered by synthetic challenges. We describe a strategy for the functionalization of purine nucleosides via photoredox and nickel-catalyzed sp

Identifiers

PMID33859805
PMCPMC8040254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.