Evidence map›Paper›PMID 33859761›Full record

ArticleTheranostics2021

Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice.

Katerina T Xenaki, Bram Dorrestijn, Joey A Muns, Kevin Adamzek, Sofia Doulkeridou, HendrikJan Houthoff, Sabrina Oliveira, Paul Mp van Bergen En Henegouwen

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Application of nanoparticles in antibody drug delivery.Frontiers in bioengineering and biotechnology · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. A high-affinity CEA-targeted nanobody forJournal of nanobiotechnology · 2025
    Article
  13. A multivalent nanobody-drug conjugate to prevent and treat influenza virus infections.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. Advances in Nanobody-Based Platforms for Precision Cancer Diagnosis and Therapy.Polymer science & technology (Washington, D.C.) · 2025
    Review
  16. Article
  17. Development and Characterization of the [Molecular pharmaceutics · 2025
    Article
  18. Article
  19. Article
  20. Preclinical evaluation and pilot clinical study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Katerina T XenakiCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Bram DorrestijnCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Joey A MunsLinXis B.V., Amsterdam, The Netherlands.
Kevin AdamzekLinXis B.V., Amsterdam, The Netherlands.
Sofia DoulkeridouCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
HendrikJan HouthoffLinXis B.V., Amsterdam, The Netherlands.
Sabrina OliveiraCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Paul Mp van Bergen En HenegouwenCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLLinXis Biopharmaceuticals (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlbuminsAminobenzoatesAnimalsAntineoplastic AgentsCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleHalf-LifeHumansImmunoconjugatesMiceMice, Inbred BALB CMice, NudeOligopeptidesSingle-Domain AntibodiesTissue DistributionAlbuminsAminobenzoatesAntineoplastic AgentsauristatinErbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesImmunoconjugatesOligopeptidesSingle-Domain Antibodiesalbumin-binding domainhalf-life extensionnanobodynanobody-drug conjugatessingle-domain antibodies

Identifiers

PMID33859761
PMCPMC8039960
OpenAlexW3137288297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.