ArticleTheranostics2021
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation.
Open access · goldAbstract read
In one paragraph
Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets.Genes, chromosomes & cancer · 2024Pooled it
- Circ_0008777 promotes head and neck squamous cell carcinoma progression by elevating c-Myc expression levels via interacting with PC4 and miR-185-3p.Translational oncology · 2026Article
- Metabolism and Immunity-Adapted Radiotherapy (M.I.A.R): A Conceptual Framework for Overcoming the Therapeutic Plateau in Clinical Radiotherapy.Current oncology (Toronto, Ont.) · 2026Review
- The role of NRF2 in human cancers: Pre-clinical insights paving the way for clinical trials.Journal of pharmaceutical analysis · 2026Review
- Context-dependent NRF2 signaling in cancer: mechanisms and precision modulation.Molecular biology reports · 2026Review
- A positive feedback loop between TKT and c-Myc drives TACE resistance in hepatocellular carcinoma.Cell death discovery · 2026Article
- The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy.Life medicine · 2026Review
- Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities.Molecular biomedicine · 2026Review
- Phytochemicals Modulating Redox Homeostasis in Head and Neck Cancer.Cell biochemistry and biophysics · 2026Review
- Immunometabolic Reprogramming in Hepatocellular Carcinoma Mechanisms, Biomarkers, and Therapeutic Implications.Oncology research · 2026Review
- Advances in ferroptosis mechanisms and therapeutic potential in head and neck squamous cell carcinoma.Frontiers in cell and developmental biology · 2026Review
- Host systemic metabolism and cancer metabolic vulnerabilities: mechanisms and therapeutic opportunities.Frontiers in oncology · 2026Review
- IL21-STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia.HemaSphere · 2026Article
- Inflammation as a master regulator of immunotherapy response in head and neck squamous cell carcinoma: from malignant transformation to ecology-aware precision combinations.Frontiers in immunology · 2026Review
- Metabolic Symbiosis Between Cancer Cells and Endothelial Cells: A Key Driver of Tumor Angiogenesis.Advances in experimental medicine and biology · 2026Review
- Effects of the Pharmacological Modulation of NRF2 in Cancer Progression.Medicina (Kaunas, Lithuania) · 2025Review
- 5'-Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation-Mediated PAK2 Upregulation to Promote Cadmium-Induced Breast Cancer Progression by Impairing Autophagic Flux.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- From Carcinogenesis to Drug Resistance: The Multifaceted Role of Oxidative Stress in Head and Neck Cancer.Cancers · 2025Review
- Extracellular vesicles from adipose-derived mesenchymal stem cells prevent high glucose-induced retinal ganglion cell pyroptosis through a microRNA-26a-5p-dependent mechanism.Journal of diabetes investigation · 2025Article
- Targeting Nrf2 in acute myeloid leukemia: an updated review on its role in chemoresistance and emerging therapeutic strategies.Medical oncology (Northwood, London, England) · 2025Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 1 country.
Ya-Chu TangGraduate Program of Medical Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Jenn-Ren HsiaoDepartment of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shih-Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Jang-Yang ChangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Pei-Yi ChuNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Ko-Jiunn LiuNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Hsun-Lang FangDepartment of Cosmetology and Health Care, Min-Hwei College of Health Care Management, Tainan, Taiwan.
Li-Mei LinInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Huang-Hui ChenInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Yen-Wen HuangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Yu-Tsen ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Su-Fang LinNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Yung-Jen ChuangInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.
Ching-Chuan KuoInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
National Health Research Institutes · TWNational Cheng Kung University · TWNational Tsing Hua University · TWChang Bing Show Chwan Memorial Hospital · TWChina Medical University · TWMin-Hwei College of Health Care Management · TW
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Biomarkers, TumorCell LineCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticGlucosephosphate DehydrogenaseHead and Neck NeoplasmsHumansMetabolic Networks and PathwaysNF-E2-Related Factor 2Oxidation-ReductionPentose Phosphate PathwayPrognosisProto-Oncogene Proteins c-mycBiomarkers, TumorG6PD protein, humanGlucosephosphate DehydrogenaseNFE2L2 protein, humanNF-E2-Related Factor 2Proto-Oncogene Proteins c-mycTransketolasec-MYCglucose-6-phosphate dehydrogenase (G6PD)head and neck squamous cell carcinoma (HNSCC)Nuclear factor erythroid 2-related factor 2 (NRF2)pentose phosphate pathway (PPP)transketolase (TKT)
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.