Evidence map›Paper›PMID 33859737›Full record

ArticleTheranostics2021

Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.

Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. CD11dGenes and immunity · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Current trends in exosomes as therapeutic drug delivery systems.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Rekindling Vision: Innovative Strategies for Treating Retinal Degeneration.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Xue DongDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Yi LeiDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Zeyang YuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Tian WangDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Yi LiuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Gang HanSchool of Medical Laboratory, Tianjin Medical University, Guangdong Road, Tianjin 300203, China.
Xiaodan ZhangDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Yiming LiDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Yinting SongDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Heping XuThe Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Mei DuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Haifang YinTianjin Key Laboratory of Cellular Homeostasis and Human Diseases & Department of Cell Biology, Tianjin Medical University, Qixiangtai Road, Heping District, Tianjin, 300070, China.
Xiaohong WangDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Hua YanDepartment of Ophthalmology, Tianjin Medical University General Hospital, 300070, Tianjin, China.
Tianjin Medical University · CNQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiogenesis InhibitorsAngiogenic ProteinsAnimalsCapillary PermeabilityCell MovementCell ProliferationCells, CulturedDisease Models, AnimalEndothelial CellsExosomesHumansHuman Umbilical Vein Endothelial CellsIntravitreal InjectionsMiceMice, Inbred C57BLNeovascularization, PathologicAngiogenesis InhibitorsAngiogenic ProteinsOxygenPeptide FragmentsVascular Endothelial Growth Factor Adrug deliveryExosomes (EXOs)pathological angiogenesisproliferative retinopathyVEGF signaling.

Identifiers

PMID33859737
PMCPMC8039955
OpenAlexW3137848301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.