Evidence map›Paper›PMID 33859685›Full record

ArticleAnesthesiology research and practice2021

Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study.

Raham Hasan Mostafa, Ahmed Mohamed Khamis, Ashraf Nabil Saleh, Yehia Mamdouh Hassan Mekki, Mohamed Mohamed Kamal, Ismail Mohammed Ibrahim, Mohamed Abdulmohsen Abdulnaiem Ismaiel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Raham Hasan MostafaDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5560-2733
Ahmed Mohamed KhamisDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-1665-0628
Ashraf Nabil SalehDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-2282-3804
Yehia Mamdouh Hassan MekkiDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-5759-8777
Mohamed Mohamed KamalDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9749-040X
Ismail Mohammed IbrahimDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5182-4195
Mohamed Abdulmohsen Abdulnaiem IsmaielDepartment of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9242-071X
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant. PURPOSE: The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. We hypothesized that a single low-dose administration of ketamine infusion during D&C surgery can improve mood scores in the immediate postoperative period.

methodsA prospective, randomized, double-blind, parallel-group, placebo-controlled trial. The study included a total of 60 patients, ≥18 years, physical status ASA II, with up to 12-week gestation undergoing elective D&C surgery. Patients were divided randomly into a ketamine group (group K) and a control group (group C). In group K, 0.4 mg/kg ketamine was given as a continuous infusion over 20 min intraoperatively.

resultsThere were no differences in preoperative POMS between the two groups. Mean postoperative POMS of group K was lower than that of group C indicating mood improvement. Ketamine group patients showed higher sedation score and increased, although self-limiting, psychedelic phenomena than the control group.

conclusionObserved data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. This trial is registered with PACTR201907779292947.

Identifiers

PMID33859685
PMCPMC8009713
OpenAlexW3139035047

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.