ArticleFrontiers in genetics2021
Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Orexin Receptor Antagonism Improves Sleep Quality and Mitigates Lipopolysaccharide-Induced Inflammatory Responses in a Mouse Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Integrated Analysis of Immune-Related Genes Reveals Altered Biological Functions and Immune Cell Abundance in Sleep DeprivationEndocrine, metabolic & immune disorders drug targets · 2026Article
- Article
- Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions.Communications biology · 2024Article
- Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation.Sleep & breathing = Schlaf & Atmung · 2024Article
- DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.Cell communication and signaling : CCS · 2024Article
- Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection.iScience · 2023Article
- Sex Inclusion in Transcriptome Studies of Daily Rhythms.Journal of biological rhythms · 2023Article
- Analysis of circadian rhythm components in EEG/EMG data of aged mice.Frontiers in neuroscience · 2023Article
- Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep.Communications biology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadian expression of approximately 3,000 genes. We found that circadian rhythm disappears in genes related to metabolism and signaling pathways regulating protein phosphorylation after acute sleep deprivation, while the core circadian regulators do not change much in rhythmicity. Importantly, the strong positive correlation between mean expression and amplitude (E-A correlation) of cycling genes has been validated in both control and sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression. Thus, we reveal that acute sleep deprivation leads to a profound change in the circadian gene transcription that influences the biological functions in lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.