Evidence map›Paper›PMID 33859640›Full record

ArticleFrontiers in immunology2021

Dynamic Intracellular Metabolic Cell Signaling Profiles During Ag-Dependent B-Cell Differentiation.

Paula Díez, Martín Pérez-Andrés, Martin Bøgsted, Mikel Azkargorta, Rodrigo García-Valiente, Rosa M Dégano, Elena Blanco, Sheila Mateos-Gomez, Paloma Bárcena, Santiago Santa Cruz and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Differential Cytokine Responses of APOE3 and APOE4 Blood-brain Barrier Cell Types to SARS-CoV-2 Spike Proteins.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Paula DíezDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Martín Pérez-AndrésDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Martin BøgstedDepartment of Haematology, Aalborg University Hospital, Aalborg, Denmark.
Mikel AzkargortaProteomics Platform, CIC bioGUNE, CIBERehd, ProteoRed-ISCIII, Derio, Spain.
Rodrigo García-ValienteProteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Rosa M DéganoProteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Elena BlancoDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Sheila Mateos-GomezDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Paloma BárcenaDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Santiago Santa CruzService of Otolaryngology and Cervical Facial Pathology, University Hospital of Salamanca, Salamanca, Spain.
Rafael GóngoraDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Félix ElortzaProteomics Platform, CIC bioGUNE, CIBERehd, ProteoRed-ISCIII, Derio, Spain.
Alicia Landeira-ViñuelaDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Pablo Juanes-VelascoDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Victor SeguraDivision of Hepatology and Gene Therapy, Proteomics and BioInformatics Unit, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Raúl Manzano-RománProteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Julia AlmeidaDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Karen DybkaerDepartment of Haematology, Aalborg University Hospital, Aalborg, Denmark.
Alberto OrfaoDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Manuel FuentesDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.
Centro de Investigación del Cáncer · ESCentro de Investigación Biomédica en Red de Cáncer · ESAalborg University Hospital · DKCentro de Investigación Biomédica en Red · ESCIC bioGUNE · ESInstituto de Investigación Biomédica de Salamanca · ESUniversidad de Navarra · ESUniversidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human B-cell differentiation has been extensively investigated on genomic and transcriptomic grounds; however, no studies have accomplished so far detailed analysis of antigen-dependent maturation-associated human B-cell populations from a proteomic perspective. Here, we investigate for the first time the quantitative proteomic profiles of B-cells undergoing antigen-dependent maturation using a label-free LC-MS/MS approach applied on 5 purified B-cell subpopulations (naive, centroblasts, centrocytes, memory and plasma B-cells) from human tonsils (data are available

Indexed as

AdolescentAdultAntigensB-Lymphocyte SubsetsCell DifferentiationCells, CulturedChildChild, PreschoolFemaleGene Expression ProfilingGene Expression RegulationGerminal CenterHumansLymphocyte ActivationMalePalatine TonsilAntigensProteomeB-cell differentiationcentroblastcentrocytememory B cellnaive B cellquantitative proteomicstranscriptomics integration

Identifiers

PMID33859640
PMCPMC8043114
OpenAlexW3139732280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.