ArticleFrontiers in systems neuroscience2021
Modulating Inhibitory Control Processes Using Individualized High Definition Theta Transcranial Alternating Current Stimulation (HD θ-tACS) of the Anterior Cingulate and Medial Prefrontal Cortex.
Article in Frontiers in systems neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of transcranial alternating current stimulation on cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study.CNS neuroscience & therapeutics · 2026Trial
- A new perspective for evaluating the efficacy of tACS and tDCS in improving executive functions: A combined tES and fNIRS study.Human brain mapping · 2024Trial
- The Interaction of the Dorsolateral and Ventromedial Prefrontal Cortex During Mind Wandering.Brain topography · 2023Trial
- Performance after training in a complex cognitive task is enhanced by high-definition transcranial random noise stimulation.Scientific reports · 2022Trial
- Modulation of prefrontal theta oscillations slows social cognition.Cognitive, affective & behavioral neuroscience · 2026Article
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Reduced task-induced frontal midline theta activity in chronic stroke patients compared to healthy older adults - An MEG study.NeuroImage. Clinical · 2026Article
- Enhanced creative thinking performance: the role of alpha frequency transcranial alternating current stimulation in the parieto-occipital region.BMC psychology · 2025Article
- Transcranial electrical stimulation (TES) in human motor Optimization: Mechanisms, safety, and emerging applications.Biochemistry and biophysics reports · 2025Review
- The simulation and experimental validation of a novel noninvasive multi-target electrical stimulation method.Scientific reports · 2025Article
- Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review.European archives of psychiatry and clinical neuroscience · 2024Review
- Neuromodulation of inhibitory control using phase-lagged transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2024Article
- Perspectives on Optimized Transcranial Electrical Stimulation Based on Spatial Electric Field Modeling in Humans.Journal of clinical medicine · 2024Review
- The Effect of Rhythmic Audio-Visual Stimulation on Inhibitory Control: An ERP Study.Brain sciences · 2024Article
- Temporal dynamics of oscillatory activity during nonlexical language decoding: Evidence from Morse code and magnetoencephalography.Human brain mapping · 2023Article
- A Review on Motor Imagery with Transcranial Alternating Current Stimulation: Bridging Motor and Cognitive Welfare for Patient Rehabilitation.Brain sciences · 2023Review
- Predicting the phase distribution during multi-channel transcranial alternating current stimulation in silico and in vivo.Computers in biology and medicine · 2023Article
- Alpha and Theta Oscillations Are Causally Linked to Interference Inhibition: Evidence from High-Definition Transcranial Alternating Current Stimulation.Brain sciences · 2023Article
- Towards causal mechanisms of consciousness through focused transcranial brain stimulation.Neuroscience of consciousness · 2023Review
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Authors and funding
12 authors.
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Abstract
Increased frontal midline theta activity generated by the anterior cingulate cortex (ACC) is induced by conflict processing in the medial frontal cortex (MFC). There is evidence that theta band transcranial alternating current stimulation (θ-tACS) modulates ACC function and alters inhibitory control performance during neuromodulation. Multi-electric (256 electrodes) high definition θ-tACS (HD θ-tACS) using computational modeling based on individual MRI allows precise neuromodulation targeting of the ACC via the medial prefrontal cortex (mPFC), and optimizes the required current density with a minimum impact on the rest of the brain. We therefore tested whether the individualized electrode montage of HD θ-tACS with the current flow targeted to the mPFC-ACC compared with a fixed montage (non-individualized) induces a higher post-modulatory effect on inhibitory control. Twenty healthy subjects were randomly assigned to a sequence of three HD θ-tACS conditions (individualized mPFC-ACC targeting; non-individualized MFC targeting; and a sham) in a double-blind cross-over study. Changes in the Visual Simon Task, Stop Signal Task, CPT III, and Stroop test were assessed before and after each session. Compared with non-individualized θ-tACS, the individualized HD θ-tACS significantly increased the number of interference words and the interference score in the Stroop test. The changes in the non-verbal cognitive tests did not induce a parallel effect. This is the first study to examine the influence of individualized HD θ-tACS targeted to the ACC on inhibitory control performance. The proposed algorithm represents a well-tolerated method that helps to improve the specificity of neuromodulation targeting of the ACC.
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