Evidence map›Paper›PMID 33859548›Full record

ArticleFrontiers in neuroscience2021

Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists.

Joaquim Azevedo Neto, Chiara Ruzza, Chiara Sturaro, Davide Malfacini, Salvatore Pacifico, Nurulain T Zaveri, Girolamo Calò

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model.Frontiers in pain research (Lausanne, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Joaquim Azevedo NetoSection of Pharmacology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Chiara RuzzaSection of Pharmacology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Chiara SturaroSection of Pharmacology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Davide MalfaciniSection of Pharmacology, Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Salvatore PacificoDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Nurulain T ZaveriAstraea Therapeutics, LLC., Mountain View, CA, United States.
Girolamo CalòDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
University of Ferrara · ITAstraea Therapeutics (United States) · USUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics.

Indexed as

AT-403functional selectivityMCOPPBmicenociceptin/orphanin FQNOP receptorRo 65-6570β arrestin 2 knockout mice

Identifiers

PMID33859548
PMCPMC8042269
OpenAlexW3146805500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.