Evidence map›Paper›PMID 33859520›Full record

ArticleInternational journal of medical sciences2021

Oral Resveratrol supplementation attenuates exercise-induced Interleukin-6 but not Oxidative Stress after a high intensity cycling challenge in adults.

Jung-Piao Tsao, Chia-Chen Liu, Hsueh-Fang Wang, Jeffrey R Bernard, Chun-Ching Huang, I-Shiung Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  14. Resveratrol and Gut Microbiota Synergy: Preventive and Therapeutic Effects.International journal of molecular sciences · 2023
    Review
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  16. Article
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  18. Resveratrol and Wine: An Overview of Thirty Years in the Digital News.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jung-Piao TsaoDepartment of Physical Education, National Taichung University of Education, Taichung City, Taiwan.
Chia-Chen LiuDepartment of Physical Education, National Taichung University of Education, Taichung City, Taiwan.
Hsueh-Fang WangDepartment of Nutrition, Institute of Biomedical Nutrition, Hungkuang University, Taichung City, Taiwan.
Jeffrey R BernardDepartment of Kinesiology, California State University, Stanislaus, Turlock, CA, USA.
Chun-Ching HuangDepartment of Exercise and Health Science, National Taipei University of Nursing and Health Science, Taipei City, Taiwan.
I-Shiung ChengDepartment of Physical Education, National Taichung University of Education, Taichung City, Taiwan.
National Taichung University of Education · TWCalifornia State University, Stanislaus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies demonstrated that resveratrol (RES) is able to enhance antioxidant, anti-inflammatory and insulin actions in humans. It is unclear whether RES can be used as ergogenic aids to enhance high-intensity cycling exercise performance and attenuate the high-intensity exercise-induced oxidative stress and inflammation. This study investigated the effect of RES supplementation on oxidative stress, inflammation, exercise-induced fatigue, and endurance performance. Eight male athletes participated in this single-blind crossover designed study and randomly instructed to receive four days of either oral RES (480 mg per day, totally 1920mg) or placebo supplementation. The cycling exercise challenge at 80% maximal oxygen consumption with 60 rpm was performed following 4 days of either RES or placebo supplementation. The total cycling performance time was recorded. In addition, blood samples were obtained to analyze the changes in blood glucose, plasma non-esterified fatty acid, serum lactate dehydrogenase, creatine kinase, uric acid, total antioxidant capacity, malondialdehyde, tumor necrosis factor-α, and interleukin-6. The exhausting time of cycling exercise challenge was not significantly increased in RES compared to that in placebo. However, IL-6 response was significantly decreased during exercise challenge in RES trial, and there were no differences in blood biomarkers, fatigue factors, and antioxidative response. Oral RES supplementation can attenuate exercise-induced IL-6 response but not fatigue and oxidative stress, inflammation response. However, we infer that 4-day oral RES supplementation has no ergogenic property on enhancing the high-intensity cycling exercise performance.

Indexed as

Administration, OralAdolescentAthletesAthletic PerformanceBicyclingCross-Over StudiesFatigueHumansInflammationInterleukin-6MaleOxidative StressPerformance-Enhancing SubstancesResveratrolSingle-Blind MethodTreatment OutcomeIL6 protein, humanInterleukin-6Performance-Enhancing SubstancesResveratrolantioxidant phytochemicalscycling exerciseergogenic propertyfatigue

Identifiers

PMID33859520
PMCPMC8040419
OpenAlexW3153838747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.