Evidence map›Paper›PMID 33859468›Full record

ArticleFederal practitioner : for the health care professionals of the VA, DoD, and PHS2021

Clinical Impact of Initiation of U-500 Insulin vs Continuation of U-100 Insulin in Subjects With Diabetes.

Alejandro Ramirez, Natalia Weare-Regales, Anthony Domingo, Arnaldo Villafranca, Krystal A Valdez, C Marcela Velez, Philip Foulis, Joaquin Gomez-Daspet

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Federal practitioner : for the health care professionals of the VA, DoD, and PHS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alejandro Ramirezis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Natalia Weare-Regalesis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Anthony Domingois Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Arnaldo Villafrancais Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Krystal A Valdezis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
C Marcela Velezis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Philip Foulisis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
Joaquin Gomez-Daspetis Assistant Chief of Endocrinology; is a staff endocrinologist; is Chief, Pathology Informatics, Pathology and Laboratory Medicine service; and is Chief of Endocrinology, Diabetes, and Metabolism section, all at the James A. Haley Veterans' Hospital in Tampa, Florida. Alejandro Ramirez and Natalia Weare-Regales are Assistant Professors, and Joaquin Gomez-Daspet is Associate Professor and Director of the Endocrinology, Diabetes and Metabolism Fellowship Training program, all at University of South Florida Morsani College of Medicine. is a Founder and Physician at Miami Endocrinology Specialists in Aventura, Florida. is a Founder and Physician at Team Endocrine in Pembroke Pines, Florida. is an Endocrinologist at First California Physician Partners in Templeton. is a Clinical Epidemiology Professor at Facultad de Medicina at Universidad de Antioquia in Medellin, Colombia.
James A. Haley Veterans' Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of obesity and diabetes mellitus (DM) has each increased drastically according to the Centers for Disease Control and Prevention. Growth of severe insulinresistant DM is predicted. U-500 insulin is highly concentrated and can replace less concentrated formulations in patients that need high insulin dosages. The aim of this study was to compare clinical outcomes of U-500 and U-100 insulin regimens in veterans with obesity and insulin resistance.

methodsA single-site retrospective chart analysis of adult subjects was conducted from July 2002 to June 2011. Data for repeated measures spanned a period from 3 months before the intervention (baseline) through 12 months afterward. The main outcome was the variation in hemoglobin A

resultsA total of 142 subjects (68 taking U-500 and 74 taking U-100) were included. Baseline characteristics were similar between the groups, except for weight, which was higher among U-500 subjects. Mean HbA

conclusionsU-500 insulin, when compared with U-100 insulin regimens, led to a statistically significant reduction in HbA

Identifiers

PMID33859468
PMCPMC8040963
OpenAlexW3154940852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.