ArticleNature medicine2021
Altered perivascular fibroblast activity precedes ALS disease onset.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 119 citations in OpenAlex.
- Article
- Unwinding the Neurovascular Unit: The Vascular Extracellular Matrix and Mechanochemical Collagen Functionalization in Vascular Dementia.International journal of molecular sciences · 2026Review
- Supplementation via DAF-16 andbioRxiv : the preprint server for biology · 2026Article
- Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.Journal of neurology · 2026Article
- Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS.BMC medicine · 2026Article
- PDGFRα is required for postnatal cerebral perivascular fibroblast development.Developmental biology · 2026Article
- From origins to nomenclature: illuminating the landscape of CNS fibroblasts and fibroblast-like cells.Acta neuropathologica communications · 2026Review
- Enlarged Perivascular Spaces (EPVS) and the Risk of Amyotrophic Lateral Sclerosis (ALS): Evidence for Overlapping Genetic Signals in White Matter Without Causal Links.Brain sciences · 2026Article
- Extracellular Matrix Remodeling in Motor Neuron Diseases.International journal of molecular sciences · 2025Review
- Fibrinogen triggers perivascular fibroblast activation in a mouse model of cortical ischemic stroke.iScience · 2025Article
- Article
- Network spreading and local biological vulnerability in amyotrophic lateral sclerosis.Communications biology · 2025Article
- Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization.BMC medicine · 2025Article
- Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model.Acta neuropathologica communications · 2025Article
- Regulation of physiological and pathological condensates by molecular chaperones.The FEBS journal · 2025Review
- Osteopontin levels in the serum reflect anatomical disease progression in patients with amyotrophic lateral sclerosis.Journal of neurology · 2025Article
- Review
- Perivascular space dysfunction in cerebral small vessel disease is related to neuroinflammation.Brain : a journal of neurology · 2025Article
- Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects.Science advances · 2025Article
- Waste clearance shapes aging brain health.Neuron · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
34 authors at 10 institutions in 6 countries.
Anna Månberg *Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0056-1313
Nathan Skene *Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Folkert SandersDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Marta TrusohamnDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0541-8903
Julia RemnestålDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.
Anna SzczepińskaDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Inci Sevval AksoyluDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Peter LönnerbergDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Lwaki EbarasiDepartment of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Stefan WoutersDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5243-6186
Manuela LehmannDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Jennie OlofssonDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8593-9089
Inti von Gohren AntequeraDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Aylin DomanikuDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7785-2143
Maxim De SchaepdryverLaboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.ORCID http://orcid.org/0000-0003-2480-863X
Joke De VochtNeurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium.
Koen PoesenLaboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.
Mathias UhlénDivision of Systems Biology, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4858-8056
Jasper AninkDepartment of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Caroline MijnsbergenDepartment of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Hermieneke Vergunst-BoschUMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, the Netherlands.
Annemarie HübersUniversity of Ulm, Neurology Clinic, Ulm, Germany.
Ulf KläppeDepartment of Neurology, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5832-038X
Elena Rodriguez-VieitezDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Jonathan D GilthorpeDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-6884-4774
Eva HedlundDepartment of Neuroscience, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6347-0075
Robert A HarrisDepartment of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4990-509X
Eleonora AronicaDepartment of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Philip Van DammeNeurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4010-2357
Albert LudolphUniversity of Ulm, Neurology Clinic, Ulm, Germany.
Jan VeldinkUMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0001-5572-9657
Caroline IngreDepartment of Neurology, Karolinska University Hospital, Stockholm, Sweden.
Peter NilssonDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4657-8532
Sebastian A LewandowskiDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden. sebastian.lewandowski@ki.se.ORCID http://orcid.org/0000-0002-5935-0211
Karolinska University Hospital · SEKarolinska Institutet · SEScience for Life Laboratory · SEAmsterdam Neuroscience · NLUmeå University · SEUniversität Ulm · DEUtrecht University · NLVIB-KU Leuven Center for Brain & Disease Research · BEKU Leuven · BEUniversitair Ziekenhuis Leuven · BE
Funding
Wellcome Trust 108726Wellcome Trust 108726/Z/15/Z
Abstract
Apart from well-defined factors in neuronal cells
Indexed as
Amyotrophic Lateral SclerosisAnimalsBiomarkersBlood VesselsCollagen Type VIDisease ProgressionDNA-Binding ProteinsFibroblastsGenetic MarkersHumansMice, TransgenicOsteopontinPrognosisRNA, MessengerSpinal CordSuperoxide DismutaseBiomarkersCol6a1 protein, humanCollagen Type VIDNA-Binding ProteinsGenetic MarkersOsteopontinRNA, MessengerSPP1 protein, humanSuperoxide Dismutase
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.