Evidence map›Paper›PMID 33859359›Full record

ArticleMolecular psychiatry2021

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Heming Wang, Raymond Noordam, Brian E Cade, Karen Schwander, Thomas W Winkler, Jiwon Lee, Yun Ju Sung, Amy R Bentley, Alisa K Manning, Hugues Aschard and 115 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients.Medical science monitor : international medical journal of experimental and clinical research · 2024
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

125 authors at 20 institutions in 12 countries.

Heming Wang *Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hwang@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-1486-7495
Raymond Noordam *Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Brian E Cade *Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1424-0673
Karen Schwander *Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Thomas W Winkler *Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Jiwon Lee *Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4079-7494
Yun Ju Sung *Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Amy R Bentley *Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0827-9101
Alisa K ManningProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7554-6783
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-8349-3028
Marjan IlkovIcelandic Heart Association, Kopavogur, Iceland.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Andrea R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Melissa RichardBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0129-9860
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Dina VojinovicDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Elise LimDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jovia L NierenbergDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.ORCID http://orcid.org/0000-0003-2376-6714
Yongmei LiuDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, USA.
Kumaraswamynaidu ChitralaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Solomon K MusaniDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Maris AlverEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Phyllis C ZeeDivision of Sleep Medicine, Department of Neurology, Northwestern University, Chicago, IL, USA.
Sarah E HarrisLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Kelly A HallSchool of Public Health, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-0171-3972
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Jeff O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5464-1792
Pamela J SchreinerDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Stephen SidneyKaiser Permanente Northern California, Oakland, CA, USA.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Annemarie I LuikDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7517-197X
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
André G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Najaf AminDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Hanfei XuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Daniel LevyDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Kurt K LohmanDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Mario SimsDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Gregory WilsonJHS Graduate Training and Education Center, Jackson State University, Jackson, MS, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8520-8860
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Walter PalmasDivision of General Medicine, Department of Medicine, Columbia University, New York, NY, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Nienke R BiermaszDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Lisa W MartinGeorge Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Ana BaracMedStar Heart and Vascular Institute, Washington, DC, USA.
Robert B WallaceDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Daniel J GottliebDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Andres MetspaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3718-796X
John M StarrAlzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, UK.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, HJ, The Netherlands.
R J WakenDivision of Cardiology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Konstantin StrauchInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Till RoennebergInstitute and Polyclinic for Occupational-, Social- and Environmental Medicine, LMU Munich, Munich, Germany.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Marcus DörrGerman Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-7471-475X
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sutapa MukherjeeSleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Adelaide, SA, Australia.
David R HillmanDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Hans J GrabeDepartment Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Lyle J PalmerSchool of Public Health, The University of Adelaide, Adelaide, SA, Australia.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Tanika N KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-0048-491X
Ervin R FoxDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-0037-411X
Timo A LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1982-6569
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Ian J DearyLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1733-263X
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, HJ, The Netherlands.
W James GaudermanDivision of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. d.van_heemst@lumc.nl.
Erasmus MC · NLHelmholtz Zentrum München · DELeiden University Medical Center · NLNational Institutes of Health · USUniversity of Washington · USWashington University in St. Louis · USBoston University · USBroad Institute · USThe University of Texas Health Science Center at Houston · USUCLA Medical Center · USUniversitätsmedizin Greifswald · DEUniversity of Tartu · EEBrigham and Women's Hospital · USJackson Memorial Hospital · USTampere University · FITulane University · USUniversity Medical Center Groningen · NLVanderbilt University · USWake Forest University · USAmsterdam Neuroscience · NL

Funding

Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9M
Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Leveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4M
Metabolomics of Neurocognitive Risk for Dementia in DiabetesR01AG058921 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLRED, NICHOLETTE D. · 2019 to 2023
$3.8M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
FAMILIAL AGGREGATION OF OBSTRUCTIVE SLEEP APNEAR01HL046380 · NHLBI · UNIVERSITY HOSPITALS OF CLEVELAND · PI REDLINE, SUSAN S · 1990 to 2005
$3.5M
Intramural NIH HHS ZIA HG200362NCI NIH HHS T32 CA112355NHLBI NIH HHS K01 HL135405NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R35 HL135818NIA NIH HHS R01 AG058921NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P

Indexed as

Genome-Wide Association StudyHypertensionBlood PressureGenetic LociHumansPolymorphism, Single NucleotideSleep

Identifiers

PMID33859359
PMCPMC8517040
OpenAlexW3155873187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.