Evidence map›Paper›PMID 33859330›Full record

ArticleScientific reports2021

Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.

Nicola Johnstone, Chiara Milesi, Olivia Burn, Bartholomeus van den Bogert, Arjen Nauta, Kathryn Hart, Paul Sowden, Philip W J Burnet, Kathrin Cohen Kadosh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
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  20. The Gut-Kidney Axis in Chronic Kidney Diseases.Diagnostics (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Nicola JohnstoneSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. nicola.johnstone@surrey.ac.uk.
Chiara MilesiSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Olivia BurnSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Bartholomeus van den BogertBaseClear, Leiden, The Netherlands.
Arjen NautaFrieslandCampina, Amersfoort, The Netherlands.
Kathryn HartDepartment of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Paul SowdenSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
Philip W J BurnetDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Kathrin Cohen KadoshSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. k.cohenkadosh@surrey.ac.uk.
University of Surrey · GBBioclear Earth (Netherlands) · NLFrieslandCampina (Netherlands) · NLUniversity of Winchester · GBWarneford Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.

Indexed as

Anti-Anxiety AgentsDietary SupplementsHealthy VolunteersPrebioticsAdolescentAdultAnxietyFemaleGastrointestinal MicrobiomeHumansTrisaccharidesYoung Adult4'-galactooligosaccharideAnti-Anxiety AgentsPrebioticsTrisaccharides

Identifiers

PMID33859330
PMCPMC8050281
OpenAlexW3152676541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.