ArticleScientific reports2021
Behavioral and brain mechanisms mediating conditioned flight behavior in rats.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Prior trauma shapes the effects of psilocybin on stress sensitization in mice.Neuroscience letters · 2026Article
- Tail-rattling in rodents: more than a threat display.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- A corticostriatal circuit mediates the switching of defensive responses to an approaching threat.Translational psychiatry · 2026Article
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- Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.iScience · 2026Article
- Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Endocannabinoid modulation of defensive state transitions to innate and learned threat.Psychopharmacology · 2026Article
- Dual sigma receptor 1 and 2 modulator improves memory behavior in mouse model of age-related cognitive decline.The Journal of pharmacology and experimental therapeutics · 2026Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
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- When Silence Breaks: The Influence of Pure Tones and White Noises on Conditioned Flight Responses.Brain and behavior · 2025Review
- A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.bioRxiv : the preprint server for biology · 2025Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
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- Defensive behaviors and c-fos expression in the midbrain.Integrative zoology · 2025Article
- Contributions of associative and non-associative learning to the dynamics of defensive ethograms.eLife · 2024Article
- Contributions of associative and non-associative learning to the dynamics of defensive ethograms.bioRxiv : the preprint server for biology · 2024Article
- Ethograms reveal a fear conditioned visual cue to organize diverse behaviors.bioRxiv : the preprint server for biology · 2024Article
- Article
- Auditory stimuli suppress contextual fear responses in safety learning independent of a possible safety meaning.Frontiers in behavioral neuroscience · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Environmental contexts can inform animals of potential threats, though it is currently unknown how context biases the selection of defensive behavior. Here we investigated context-dependent flight responses with a Pavlovian serial-compound stimulus (SCS) paradigm that evokes freeze-to-flight transitions. Similar to previous work in mice, we show that male and female rats display context-dependent flight-like behavior in the SCS paradigm. Flight behavior was dependent on contextual fear insofar as it was only evoked in a shock-associated context and was reduced in the conditioning context after context extinction. Flight behavior was only expressed to white noise regardless of temporal order within the compound. Nonetheless, rats that received unpaired SCS trials did not show flight-like behavior to the SCS, indicating it is associative. Finally, we show that pharmacological inactivation of two brain regions critical to the expression of contextual fear, the central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), attenuates both contextual fear and flight responses. All of these effects were similar in male and female rats. This work demonstrates that contextual fear can summate with cued and innate fear to drive a high fear state and transition from post-encounter to circa-strike defensive modes.
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