Evidence map›Paper›PMID 33859252›Full record

ArticleScientific reports2021

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

Gijs A C Franken, Murat Seker, Caro Bos, Laura A H Siemons, Bram C J van der Eerden, Annabel Christ, Joost G J Hoenderop, René J M Bindels, Dominik Müller, Tilman Breiderhoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Gijs A C Franken *Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.
Murat Seker *Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Caro BosDepartment of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.
Laura A H SiemonsDepartment of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.
Bram C J van der EerdenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Annabel ChristDepartment of Molecular Cardiovascular Research, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
Joost G J HoenderopDepartment of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.
René J M BindelsDepartment of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.
Dominik MüllerDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Tilman BreiderhoffDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jeroen H F de BaaijDepartment of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands. jeroen.debaaij@radboudumc.nl.
Radboud Institute for Molecular Life Sciences · NLCharité - Universitätsmedizin Berlin · DERadboud University Nijmegen · NLErasmus MC · NLMax Delbrück Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg

Indexed as

AnimalsAnimals, NewbornCation Transport ProteinsEmbryo, MammalianFemaleIntellectual DisabilityMagnesiumMagnesium DeficiencyMaleMiceMice, Inbred C57BLMice, KnockoutPregnancySeizuresCation Transport ProteinsCnnm2 protein, mouseMagnesium

Identifiers

PMID33859252
PMCPMC8050252
OpenAlexW3154285740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.