Evidence map›Paper›PMID 33859251›Full record

ArticleScientific reports2021

Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network.

Leila Sadeghi, Albert Anatolyevich Rizvanov, Bahareh Dabirmanesh, Ilnur Ildusovich Salafutdinov, Mohammad Sayyah, Amir Shojaei, Javad Zahiri, Javad Mirnajafi-Zadeh, Babak Khorsand, Khosro Khajeh and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  8. Overrepresentation of Enterobacteriaceae andFrontiers in cellular and infection microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Leila SadeghiDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Albert Anatolyevich RizvanovInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation.ORCID 0000-0002-9427-5739
Bahareh DabirmaneshDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Ilnur Ildusovich SalafutdinovInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation.
Mohammad SayyahDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Amir ShojaeiDepartment of Medical Physiology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Javad ZahiriDepartment of Biophysics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.ORCID 0000-0002-8360-2458
Javad Mirnajafi-ZadehDepartment of Medical Physiology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Babak KhorsandDepartment of Computer Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Khosro KhajehDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran. khajeh@modares.ac.ir.
Yaghoub FathollahiDepartment of Medical Physiology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran. fatolahi@modares.ac.ir.
Tarbiat Modares University · IRKazan Federal University · RUFerdowsi University of Mashhad · IRPasteur Institute of Iran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures. A total of 144 differently expressed proteins in both left and right hippocampi by two-dimensional electrophoresis coupled to matrix-assisted laser desorption-mass spectrometry were identified across the rat models of epilepsy. Based on network analysis, the majority of differentially expressed proteins were associated with Ca

Indexed as

Kindling, NeurologicPilocarpineProteomicsADP-ribosyl CyclaseAnimalsCalciumCyclic ADP-RiboseDisease Models, AnimalElectrophoresisEpilepsyHippocampusHomeostasisMaleMolecular Targeted TherapyRatsRats, Wistar8-bromo-cyclic-ADP-riboseADP-ribosyl CyclaseCalciumCyclic ADP-RibosePilocarpineReceptors, Lysophosphatidic AcidSnap25 protein, ratSynaptosomal-Associated Protein 25

Identifiers

PMID33859251
PMCPMC8050094
OpenAlexW3156608979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.