Observational studyNature communications2021
Real-world stress resilience is associated with the responsivity of the locus coeruleus.
Observational study in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
55 citing papers in PubMed, 105 citations in OpenAlex.
- Subtype-resolved norepinephrine imaging with an engineered αCell reports methods · 2026Article
- The locus coeruleus at the crossroads of inflammation and neurodegeneration in multiple sclerosis.Journal of neuroinflammation · 2026Review
- Psychological stress during medical internship is associated with inflammatory signatures linked to mental health.Brain, behavior, & immunity - health · 2026Article
- Stress, stress systems, and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Pupil-based arousal self-regulation: impact on physiological and affective responses to emotional stimuli.Translational psychiatry · 2026Article
- Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults.Neurobiology of aging · 2026Article
- Anatomical and Neuronal Distribution of the G-Coupled Protein Receptor 75 mRNA in the Mouse Central Nervous System.The European journal of neuroscience · 2026Article
- A Tripartite Framework of Conflict-Induced Stress, Acoustic Hypervigilance, and Ramadan Observance as Convergent Determinants of Circadian Decoherence in Athletes.Nature and science of sleep · 2026Review
- Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.Psychology and aging · 2025Article
- The role of the salience network in adolescent impulsivity using memory tasks and neuroimaging.Communications medicine · 2025Article
- Dexmedetomidine elicits a prolonged anxiolytic effect by inhibiting adrenergic neurons in the locus coeruleus in mice.Translational psychiatry · 2025Article
- Understanding resilience in medical interns through ecological momentary assessments, predictive modelling, and topic analysis.Communications medicine · 2025Article
- Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases.bioRxiv : the preprint server for biology · 2025Article
- Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults.bioRxiv : the preprint server for biology · 2025Article
- Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence.JAMA network open · 2025Article
- Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025Review
- The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.Brain communications · 2025Article
- Depression and metabolic connectivity: insights into the locus coeruleus, HF-rTMS, and anxiety.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.