Evidence map›Paper›PMID 33859181›Full record

ArticleNature communications2021

Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate.

Francesca Rapino, Zhaoli Zhou, Ana Maria Roncero Sanchez, Marc Joiret, Christian Seca, Najla El Hachem, Gianluca Valenti, Sara Latini, Kateryna Shostak, Liesbet Geris and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Multi-omics analysis identifies a role forMicrobiology spectrum · 2026
    Article
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  5. Advances in RNA modification in myocardial fibrosis (Review).International journal of molecular medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 3 countries.

Francesca Rapino *Laboratory of Cancer Signaling, University of Liège, Liège, Belgium. Francesca.Rapino@uliege.be.
Zhaoli Zhou *Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
Ana Maria Roncero Sanchez *Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
Marc JoiretLaboratory of Cancer Signaling, University of Liège, Liège, Belgium.
Christian SecaLaboratory of Cancer Signaling, University of Liège, Liège, Belgium.
Najla El HachemLaboratory of Cancer Signaling, University of Liège, Liège, Belgium.ORCID 0000-0002-4180-3016
Gianluca ValentiUniversity of Liège, Liège, Belgium.
Sara LatiniLaboratory of Cancer Signaling, University of Liège, Liège, Belgium.ORCID 0000-0002-2353-3155
Kateryna ShostakGIGA-Institute, University of Liège, Liège, Belgium.
Liesbet GerisGIGA-Institute, University of Liège, Liège, Belgium.ORCID 0000-0002-8180-1445
Ping LiShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Gang HuangShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Gabriel MazzucchelliGIGA-Institute, University of Liège, Liège, Belgium.
Dominique BaiwirGIGA-Institute, University of Liège, Liège, Belgium.ORCID 0000-0002-1622-0118
Christophe J DesmetGIGA-Institute, University of Liège, Liège, Belgium.
Alain ChariotGIGA-Institute, University of Liège, Liège, Belgium.
Michel GeorgesGIGA-Institute, University of Liège, Liège, Belgium.
Pierre CloseLaboratory of Cancer Signaling, University of Liège, Liège, Belgium. Pierre.Close@uliege.be.ORCID 0000-0002-8844-9616
University of Liège · BEShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of mRNA translation elongation impacts nascent protein synthesis and integrity and plays a critical role in disease establishment. Here, we investigate features linking regulation of codon-dependent translation elongation to protein expression and homeostasis. Using knockdown models of enzymes that catalyze the mcm

Indexed as

Peptide Chain Elongation, TranslationalRNA Processing, Post-TranscriptionalAmino AcidsCell Line, TumorCodon UsageGene Knockdown TechniquesHumansHydrophobic and Hydrophilic InteractionsMultienzyme ComplexesProtein AggregatesProteolysisProteomicsRNA, MessengerRNA, TransferUridineAmino AcidsMultienzyme ComplexesProtein AggregatesRNA, MessengerRNA, TransferUridine

Identifiers

PMID33859181
PMCPMC8050329
OpenAlexW3155869633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.