Evidence map›Paper›PMID 33859042›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Interferon regulatory factor 4 controls effector functions of CD8

Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Friederike Raczkowski

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 37 citations in OpenAlex.

  1. Interferon regulatory factors orchestrate CD8International journal of molecular medicine · 2026
    Review
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  8. Review
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  11. Engineering resilient CAR T cells for immunosuppressive environment.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  12. Article
  13. Article
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  15. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aenne HarbertsInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-0143-8106
Constantin SchmidtInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-3892-4255
Joanna SchmidInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-7540-960X
Daniel ReimersInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2225-2001
Friedrich Koch-NolteInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-1730-6674
Hans-Willi MittrückerInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany h.mittruecker@uke.de f.raczkowski@uke.de.ORCID 0000-0001-6166-4191
Friederike RaczkowskiInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany h.mittruecker@uke.de f.raczkowski@uke.de.ORCID 0000-0002-4139-0565
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor IRF4 is required for CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationFemaleImmunologic MemoryInterferon Regulatory Factor-4Interferon Regulatory FactorsListeria monocytogenesLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutInterferon Regulatory Factor-4Interferon Regulatory FactorsCD8+ T cellsinterferon regulatory factor 4Listeria monocytogenesmemory T cells

Identifiers

PMID33859042
PMCPMC8072204
OpenAlexW3156655100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.