ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.CNS neuroscience & therapeutics · 2026Article
- Whole-Brain Monosynaptic Inputs and Outputs of Corticotropin-Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice.CNS neuroscience & therapeutics · 2026Article
- Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension.The Journal of clinical investigation · 2026Article
- Oxytocin and Vasopressin Cross Talk Within the Brain Increases Blood Pressure.Circulation research · 2026Article
- Autonomic imbalance and vascular injury in hypertensive chronic kidney disease: mechanisms and clinical potential of ultrasound-guided sympathetic blockade.Frontiers in neuroscience · 2026Review
- Cellular and Molecular Architecture of Renin-Angiotensin System Signaling in the PVN Under Cardiometabolic Stress.bioRxiv : the preprint server for biology · 2025Article
- Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Direct Modulation of CRH Nerve Terminal Function by Noradrenaline and Corticosterone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- PTSD Increases Risk for Hypertension Development Through PVN Activation and Vascular Dysfunction in Sprague Dawley Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Impaired oxytocin signalling in the central amygdala in rats with chronic heart failure.The Journal of physiology · 2024Article
- Alleviating Hypertension by Selectively Targeting Angiotensin Receptor-Expressing Vagal Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition.Biological psychiatry global open science · 2024Review
- Impaired oxytocin signaling in the central amygdala in rats with chronic heart failure.bioRxiv : the preprint server for biology · 2023Article
- Recruitment of Corticotropin-Releasing Hormone (CRH) Neurons in Categorically Distinct Stress Reactions in the Mouse Brain.International journal of molecular sciences · 2023Article
- Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear-potentiated startle.Journal of cellular physiology · 2023Article
- Leptin Increases: Physiological Roles in the Control of Sympathetic Nerve Activity, Energy Balance, and the Hypothalamic-Pituitary-Thyroid Axis.International journal of molecular sciences · 2023Review
- Sodium Intake and Disease: Another Relationship to Consider.Nutrients · 2023Review
- Ventromedial hypothalamus relays chronic stress inputs and exerts bidirectional regulation on anxiety state and related sympathetic activity.Frontiers in cellular neuroscience · 2023Article
- Editorial: The neuroendocrine, autonomic and neuroinflammatory stress axes in cardiometabolic disease.Frontiers in physiology · 2023Article
- ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Khalid ElsaafienDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32611.
Matthew K KirchnerNeuroscience Institute, Georgia State University, Atlanta, Georgia 30302.ORCID https://orcid.org/0000-0001-6960-7685
Mazher MohammedDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32611.
Sophia A EikenberryDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32611.
Chloe WestNeuroscience Institute, Georgia State University, Atlanta, Georgia 30302.
Karen A ScottDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32611.
Annette D de KloetDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32611.ORCID https://orcid.org/0000-0002-7213-6957
Javier E SternNeuroscience Institute, Georgia State University, Atlanta, Georgia 30302 ekrause@cop.ufl.edu jstern@gsu.edu.
Eric G KrauseDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32611 ekrause@cop.ufl.edu jstern@gsu.edu.
American Association of Colleges of Pharmacy · USGeorgia State University · USUniversity of Florida Health · USUniversity of Florida · US
Funding
Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9MNeurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8MAltered CNS Intercellular Signaling Mechanisms in Cardiovascular DiseaseR01HL090948 · NHLBI · UNIVERSITY OF CINCINNATI · PI STERN, JAVIER E · 2008 to 2017
$3.0MInterrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9MCentral Mechanisms Underlying the Stress Dampening Effects of Acute HypernatremiaR01HL122494 · NHLBI · UNIVERSITY OF FLORIDA · PI KRAUSE, ERIC GERALD · 2015 to 2019
$1.9MDENDRITIC RELEASE OF NEUROPEPTIDES: ROLE IN BODILY HOMEOSTASISR01NS094640 · NINDS · GEORGIA STATE UNIVERSITY · PI STERN, JAVIER E · 2016 to 2020
$1.4MNovel role of central AT2R in blood pressure regulationR00HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2016 to 2018
$746kCentral Angiotensin receptors and teh neural control of homeostasisR00HL096830 · NHLBI · UNIVERSITY OF FLORIDA · PI KRAUSE, ERIC GERALD · 2011 to 2013
$727kCentral AT1 receptors and the integrated stress response.K99HL096830 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRAUSE, ERIC GERALD · 2009 to 2010
$248kNovel role of central AT2R in blood pressure regulationK99HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2015 to 2016
$225kNHLBI NIH HHS K99 HL096830NHLBI NIH HHS K99 HL125805NHLBI NIH HHS R00 HL096830NHLBI NIH HHS R00 HL125805NHLBI NIH HHS R01 HL090948NHLBI NIH HHS R01 HL122494NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750NINDS NIH HHS R01 NS094640
Abstract
The hypothalamic paraventricular nucleus (PVN) controls neuroendocrine axes and the autonomic nervous system to mount responses that cope with the energetic burdens of psychological or physiological stress. Neurons in the PVN that express the angiotensin Type 1a receptor (PVN
Indexed as
AnimalsAutonomic Nervous SystemBlood PressureHypothalamo-Hypophyseal SystemMaleMiceNeuronsParaventricular Hypothalamic NucleusPituitary-Adrenal SystemVasoconstrictionautonomiccardiovascularglucocorticoidsHPA axishypertensionstress
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.