ReviewEuropean journal of internal medicine2021
Obesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study.
Review in European journal of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Association of Body Mass Index with SARS-CoV-2 Infection in Inflammatory Arthritis Patients Receiving Biologic Therapy: Singapore National Biologics Register Findings.International journal of rheumatic diseases · 2026Article
- Genetic correlations and causal associations between BMI, HDL-C, and postoperative infections: a two-sample Mendelian randomization study.Scientific reports · 2025Article
- Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches.Biomolecules · 2024Review
- The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health.GeroScience · 2024Review
- Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review).Experimental and therapeutic medicine · 2023Review
- Naringin Alleviates Glucose-Induced Aging by Reducing Fat Accumulation and Promoting Autophagy inNutrients · 2023Article
- Adiponectin, Leptin, and Resistin Are Dysregulated in Patients Infected by SARS-CoV-2.International journal of molecular sciences · 2023Article
- The syndromic triad of COVID-19, type 2 diabetes, and malnutrition.Frontiers in nutrition · 2023Review
- ACE2 polymorphisms impact COVID-19 severity in obese patients.Scientific reports · 2022Article
- Obesity, Diabetes Mellitus, and Metabolic Syndrome: Review in the Era of COVID-19.Clinical nutrition research · 2022Review
- Huangshan Maofeng Green Tea Extracts Prevent Obesity-Associated Metabolic Disorders by Maintaining Homeostasis of Gut Microbiota and Hepatic Lipid Classes in Leptin Receptor Knockout Rats.Foods (Basel, Switzerland) · 2022Article
- Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity.International journal of molecular sciences · 2022Review
- Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19.International journal of environmental research and public health · 2021Review
- Assessing Predictive Factors of COVID-19 Outcomes: A Retrospective Cohort Study in the Metropolitan Region of São Paulo (Brazil).Medicina (Kaunas, Lithuania) · 2021Article
- The vicious cycle: a history of obesity and COVID-19.BMC cardiovascular disorders · 2021Article
- Recent Progress in Metabolic Syndrome Research and Therapeutics.International journal of molecular sciences · 2021Review
- COVID-19 and Obesity: Overlapping of Two Pandemics.Obesity facts · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.