ArticleBMC microbiology2021
Correlation between the spatial distribution and colony size was common for monogenetic bacteria in laboratory conditions.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Cleaning reshapes bacterial communities in public toilets through disturbance and random reassembly.Scientific reports · 2026Article
- Bacterial growth in poly(vinyl alcohol) hydrogel with nutrients and indicator.Scientific reports · 2026Article
- Changes in epistatic green-beard alleles induce domain shift in hypostatic rock-paper-scissors-like green-beard competition.NPJ systems biology and applications · 2025Article
- Bio-based polylactic acid labware as a sustainable alternative for microbial cultivation in life science laboratories.Heliyon · 2024Article
- Article
- Contribution of the genomic and nutritional differentiation to the spatial distribution of bacterial colonies.Frontiers in microbiology · 2022Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeographically separated population growth of microbes is a common phenomenon in microbial ecology. Colonies are representative of the morphological characteristics of this structured population growth. Pattern formation by single colonies has been intensively studied, whereas the spatial distribution of colonies is poorly investigated.
resultsThe present study describes a first trial to address the questions of whether and how the spatial distribution of colonies determines the final colony size using the model microorganism Escherichia coli, colonies of which can be grown under well-controlled laboratory conditions. A computational tool for image processing was developed to evaluate colony density, colony size and size variation, and the Voronoi diagram was applied for spatial analysis of colonies with identical space resources. A positive correlation between the final colony size and the Voronoi area was commonly identified, independent of genomic and nutritional differences, which disturbed the colony size and size variation.
conclusionsThis novel finding of a universal correlation between the spatial distribution and colony size not only indicated the fair distribution of spatial resources for monogenetic colonies growing with identical space resources but also indicated that the initial localization of the microbial colonies decided by chance determined the fate of the subsequent population growth. This study provides a valuable example for quantitative analysis of the complex microbial ecosystems by means of experimental ecology.
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