Evidence map›Paper›PMID 33858243›Full record

ArticleInnate immunity2021

A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis.

Alan S Cross, Steven M Opal, John E Palardy, Surekha Shridhar, Scott M Baliban, Alison J Scott, Abdullah B Chahin, Robert K Ernst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. The role of bacterial translocation in sepsis: a new target for therapy.Therapeutic advances in gastroenterology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alan S CrossCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, USA.ORCID 0000-0003-4362-9936
Steven M OpalDivision of Infectious Diseases, Rhode Island Hospital, USA.
John E PalardyInfectious Disease Division, Memorial Hospital of RI, USA.
Surekha ShridharCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, USA.
Scott M BalibanCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, USA.
Alison J ScottDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, USA.
Abdullah B ChahinCritical Care Division, Kent County Hospital, USA.
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, USA.
University of Maryland, Baltimore · USKent Hospital · USMemorial Hospital · USRhode Island Hospital · US

Funding

Novel Vaccine For Multidrug-Resistant Gram-negative Bacterial InfectionsR21AI135561 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CROSS, ALAN S., ERNST, ROBERT K · 2018 to 2019
$425k
NIAID NIH HHS R21 AI135561
6 · The paper itself

Abstract

Despite the dramatic increase in antimicrobial resistance, there is a dearth of antibiotics in development and few pharmaceutical companies working in the field. Further, any new antibiotics are likely to have a short shelf life. Ab-based interventions offer alternatives that are not likely to be circumvented by the widely prevalent antibiotic resistance genes. Bovine colostrum (BC)-the first milk after parturition, rich in nutrients and immune components-promotes gut integrity and modulates the gut microbiome. We developed a hyperimmune BC (HBC) enriched in Abs to a highly conserved LOS core region of Gram-negative bacteria by immunizing pregnant cows with a vaccine comprised of detoxified LOS from

Indexed as

AnimalsAntibodies, BacterialBacterial LoadBacterial Outer Membrane ProteinsBacterial VaccinesCattleEndotoxinsEscherichia coliImmunoglobulin GImmunoglobulinsLipopolysaccharidesModels, AnimalPilot ProjectsSepsisAntibodies, BacterialBacterial Outer Membrane ProteinsBacterial VaccinesEndotoxinsImmunoglobulin GImmunoglobulinsLipopolysaccharidesAntibodyantimicrobial resistancebovine colostrumendotoxinPseudomonas aeruginosa

Identifiers

PMID33858243
PMCPMC8054147
OpenAlexW3154261709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.