SynthesisJournal of the National Comprehensive Cancer Network : JNCCN2021
Characteristics Associated With Functional Changes During Systemic Cancer Treatments: A Systematic Review Focused on Older Adults.
Synthesis in Journal of the National Comprehensive Cancer Network : JNCCN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer.Journal of the American Geriatrics Society · 2025Trial
- Primary Treatment Modification and Treatment Tolerability Among Older Chemotherapy Recipients With Advanced Cancer.JAMA network open · 2024Trial
- Family Bonds at the End of Life: A Qualitative Study of Meaning Reconstruction Through Intergenerational Relationships Among Older Adults With Advanced Lung Cancer.Psycho-oncology · 2026Article
- Article
- Factors associated with functional status among older adults with colorectal cancer receiving chemotherapy in Thailand: A cross-sectional study.Belitung nursing journal · 2026Article
- Associations Between G8 Geriatric Screening Score, Charlson Comorbidity Index, AI-Based Age Phenotype, and Overall Survival in Older Adults With Stage I-II Non-Small Cell Lung Cancer.International journal of radiation oncology, biology, physics · 2025Article
- Assessment of the functional and health-related needs of patients with metastatic breast cancer prior to initiation of cancer treatment.Breast cancer research and treatment · 2025Article
- Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer.JAMA network open · 2025Article
- Smartphone application for longitudinal home gait speed measurement in older adults with blood cancers: A feasibility and acceptability study.Journal of geriatric oncology · 2025Article
- Review
- Factors Associated with Discharge Destination in Patients with Bone Metastases.Medicina (Kaunas, Lithuania) · 2024Article
- Preferences on Delivery of Cancer Rehabilitation Services for Cancer-Related Disability Among Older Individuals Surviving Breast Cancer: A Qualitative Study.Rehabilitation oncology (American Physical Therapy Association. Oncology Section) · 2023Article
- Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study.Journal of geriatric oncology · 2023Article
- Evaluation of the key geriatric assessment constructs in primary brain tumor population - a descriptive study.Journal of geriatric oncology · 2022Article
- "You have to be sure that the patient has the full picture": Adaptation of the Best Case/Worst Case communication tool for geriatric oncology.Journal of geriatric oncology · 2022Article
- Functional Status and Survival in Older Nursing Home Residents With Advanced Non-Small-Cell Lung Cancer: A SEER-Medicare Analysis.JCO oncology practice · 2022Article
- Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer.JTO clinical and research reports · 2022Article
- Article
- Review
- Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study.Journal of the American Geriatrics Society · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundMaintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.
methodsWe searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125). Findings were summarized with descriptive statistics. Study characteristics between older adult-specific and non-older adult-specific studies were compared using the Fisher exact test.
resultsWe screened 15,244 titles/abstracts and 519 full texts. The final analysis included 44 studies, which enrolled >8,400 patients; 39% of studies focused on older adults (1 study enrolled adults aged ≥60 years, 10 enrolled adults aged ≥65 years, and 6 enrolled adults aged ≥70 years). Almost all studies (98%) used patient-reported outcomes to measure functional status; only 20% used physical performance tests. Reporting of functional change was heterogeneous, with 48% reporting change scores. Older adult-specific studies were more likely to analyze functional change dichotomously (29% vs 4%; P=.008). Functional decline ranged widely, from 6% to 90%. The most common patient characteristics associated with functional decline were older age (n=7 studies), worse performance status (n=4), progressive disease status (n=4), pain (n=4), anemia (n=4), and worse nutritional status (n=4). Twelve studies examined functional improvement and identified 11 unique associated characteristics.
conclusionsFunctional decline is increasingly recognized as an important outcome in older adults with cancer, but definitions and analyses are heterogeneous, leading to a wide range of prevalence. To identify patients at highest risk of functional decline during systemic cancer treatments, trials need to routinely analyze functional outcomes and measure characteristics associated with decline (eg, nutrition).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.