SynthesisJournal of psychiatric research2021
A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.
Synthesis in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- The Research Domain Criteria (RDoC) and Youth Depression - In Context.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026Article
- Research Review: A scoping review exploring the needs, barriers, and facilitators to the collection of biological data in adolescence for mental health research.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression - An IDEA RiSCo prospective cohort study.Molecular psychiatry · 2026Article
- Prevalence, severity, and risk factors for depressive and anxiety symptoms among adolescents: A cross-sectional study.World journal of psychiatry · 2026Article
- The Eph-ephrin system in neuropsychiatric and neurodevelopmental disorders.Journal of psychiatry & neuroscience : JPN · 2026Review
- The relationship between household economic shocks, depression, and elevated stress-responsive biomarkers among adolescent girls and young women in rural South Africa (HPTN 068).Journal of affective disorders · 2025Article
- Diagnostic and Predictive Utility of Plasma Phosphoethanolamine Levels in Depressive Disorder: A Naturalistic Observational Study.International journal of methods in psychiatric research · 2025Observational
- Well-being and biological cost of family members affected by substance use disorder of others.European archives of psychiatry and clinical neuroscience · 2025Article
- Adolescent depression, childhood maltreatment, and the immune system; a role for epigenetic aging?Brain, behavior, & immunity - health · 2025Article
- Death recollection moderates stress-influenced depression in Thai boarding school students.BMC psychology · 2025Article
- Depression in left-behind adolescents from single-parent families: a nomogram based on multidimensional risk factors.Child and adolescent psychiatry and mental health · 2025Article
- How environmental perception influence depression and anxiety: the mediating role of social interaction.BMC public health · 2025Article
- Adherence to the Mediterranean Diet and Risk of Depression: A Cohort Study in Chinese Community Residents.Nutrients · 2025Article
- Association between the Balanced Healthy Eating Index and depression and the mediating role of extreme pessimistic thoughts: an analysis from the health and nutrition database.Frontiers in nutrition · 2025Article
- The Interaction Between Family Functioning and thePsychology research and behavior management · 2025Article
- Ventral striatal-cingulate resting-state functional connectivity in healthy adolescents relates to later depression symptoms in adulthood.Journal of affective disorders · 2024Article
- Defining and distinguishing early life stress, trauma, adversity, toxic and chronic stress and allostatic load: a descriptive review.Scandinavian journal of public health · 2024Review
- Article
- Inflammation and immune system pathways as biological signatures of adolescent depression-the IDEA-RiSCo study.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionAlthough the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.
methodsWe searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.
findingsOf 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.
interpretationThe developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.